Results 171 to 180 of about 1,951,358 (319)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The impact of individualism - Collectivism, social presence, and group diversity on group decision making under majority influence

, 2007
Majority influence is the attempt by a majority of group members to impose their common position on group dissenters during group decision making. Because of globalization, the use of cross-cultural teams in group tasks is becoming increasingly common ...
Lowry, Paul Benjamin, Fu, Xiaolan, Zhang, Dongsong, Zhou, Lina   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Safeguarding children and strengthening families through the application and utilization of family group decision making: A systematic review protocol. [PDF]

PLoS One
Ngadhi CM, Wareley S, Joseph P, Johannes C, Spolander G, Roman NV.   +5 more
europepmc   +1 more source

A web-based software for group decision with analytic hierarchy process. [PDF]

MethodsX, 2023
Françozo RV, Junior LSVU, Carrapateira ES, Pacheco BCS, Oliveira MT, Torsoni GB, Yari J.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Editorial: Neuropsychology of human social decision-making: the role of emotions

Frontiers in Neuroscience
X. T. Wang, Sarah Hill, Hongjian Cao
doaj   +1 more source

A multi-objective optimization consensus model for large-scale group decision-making considering dynamic social networks. [PDF]

Sci Rep
Chen G, Lang A, Han X, Fu J, Liu X.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Enhancing strategic basketball decisions using a bipolar complex fuzzy multi criteria group decision making framework. [PDF]

Sci Rep
Yao J, Wang X, Wei Q, Cheng Y.
europepmc   +1 more source