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Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source
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Group Decision Making

The Business & Management Collection, 2011
This chapter introduces a multicriteria decision making method for measuring intangible criteria alongside tangible ones. It relies on the use of judgments when scales are unavailable, and because scales of measurement use arbitrary units uniformly over their entire range, judgment is often needed to determine the significance of reading on such a ...
  +4 more sources

Group decision-making

2014
Decision making by individuals and its relation to rationality is an important area of research because it allows individuals to make effective decisions. Decision making in groups is when individuals come together and make decisions in whatever manner that is feasible.
  +5 more sources

Group Decision Making

2013
This chapter will deal with situations involving several possibilities that can and should be ranked—for example parties at an election, singers at a singing competition or the variations given in the traffic routing in a city.
Hans-Joachim Bungartz   +3 more
openaire   +2 more sources

Group decision making

Evaluation Practice, 1986
Jean Mayer Foreward Walter C Swap Preface Jeffrey Z Rubin Introduction Walter C Swap How Groups Make Decisions A Social Psychological Perspective Walter C Swap Destructive Effects of Groups on Individuals Richard A Chechile Logical Foundations for a Fair and Rational Method of Voting Hugo Bedau Ethical Aspects of Group Decision Making Sheldon Krimsky ...
Margaret A. Neale, Walter C. Swap
openaire   +2 more sources

Group Decision-Making

2023
Torsten Reimer   +2 more
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