Results 121 to 130 of about 1,170,336 (314)

Human erroranalysis among petrochemical plant control room operators with human errorassessment and reduction technique

Salāmat-i kār-i Īrān, 2009
Background and aims Control room is a palpitating heart of a system, and any error in operator`s duties have irreparable consequences. Nowadays, in many work places such as nuclear industry, military and chemical parts human error can cause catastrophic ...
S. Varmazyar, SB. Mortazavi, H. Asilian, M. Ghalenoei   +3 more
doaj  

Level and limitations of physical activity in patients with excess body weight or diabetes

BMJ Open Sport & Exercise Medicine
Physical activity (PA) is recommended to prevent or treat many diseases, but various factors may limit it. We analyse the level of PA and the barriers to undertaking it.
Edyta Sutkowska, Karolina Biernat, Justyna Mazurek, Katarzyna Hap, Natalia Kuciel, Magdalena Sutkowska, Dominik Marciniak   +6 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Group Duties. Their Existence and Their Implications for Individuals (Stephanie Collins)

Gogoa, 2019
Betebeharren inguruko hausnarketa filosofikoa zerbait berria ez bada ere, azkenengo urteetan gero eta analisi filosofiko gehiago agertzen eta eztabaidatzen ari dira. Era berean, egungo ontologia sozialak “talde” moduko entitate sozialen ikerketa zaharra tresna sofistikatuagoekin eraberritu du. Erraza da betebeharrak eta entitate sozialak harreman estua
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Sovereign Debt Reform and the Best Interest of Creditors [PDF]

, 2004
In April 2002 the International Monetary Fund introduced a sovereign bankruptcy proposal only to be rebuffed by the United States Treasury. Where the IMF wanted a mandatory bankruptcy regime, the Treasury wanted to solve distress problems with ...
Bratton, William W., Gulati, G. Mitu
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Distribution of sleep components while working remotely

International Journal of Occupational Medicine and Environmental Health
Objectives The circadian system is the main regulator of almost all human physiological processes. The aim of this study was to assess sleep in the working population, in relation to the share of remote working. Material and Methods An online survey was
Magdalena Janc, Agnieszka Jankowska, Zbigniew Jozwiak, Teresa Makowiec-Dabrowska, Joanna Jurewicz, Kinga Polanska   +5 more
doaj   +1 more source