Results 121 to 130 of about 104,801 (306)
Delphi Method and Nominal Group Techniques in Family Planning and Reproductive Health Research
, 2006 Both the Delphi method and nominal group technique offer structured, transparent and replicable ways of synthesising individual judgements and have been used extensively for priority setting and guideline development in health-related research including ...
Edwin van Teijlingen (64309) +7 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2015 By duty scholars, judges and legislators usually mean the position of a natural or legal person obliged towards one or more others having a right whose content is the same claim. According to the classical definitions of W.H.
Ferrari, Giuseppe Franco
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The WTO negotiations broke down on July 30th, 2008 because members could not bridge their differences over the operation of a Special Safeguard Mechanism (SSM). This article evaluates the latest SSM proposal using the world wheat market as our case study.
Meilke, Karl D., Grant, Jason H.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Estimating the differential exposure of household groups to alcohol duty reforms in Great Britain
Journal of Public HealthAbstract Background We explored the potential impact of changes to the UK alcohol tax system implemented in August 2023 on increases on consumer spending, the separate impacts of the changes to the duty structures, and how these impacts vary between households depending on their level of ...
Wilson, L.B. +4 more
openaire +4 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
NAMA Negotiations in the WTO and Preference Erosion: Concerns of Bangladesh and Other Regional LDCs [PDF]
The ongoing negotiations on non-agricultural market access (NAMA) in the WTO are expected to lead to substantive reductions in the tariff rates on industrial goods in both the developed and the developing countries.
Mustafizur Rahman, Wasel Bin Shadat
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source