Results 111 to 120 of about 1,170,336 (314)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Special Libraries, April 1936 [PDF]
, 1934 Volume 27, Issue 4https://scholarworks.sjsu.edu/sla_sl_1936/1003/thumbnail ...
Special Libraries Association
core +6 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Assessment of physical and special training of border guards to the profession the first age group [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012 The problem of managing the physical and special training of troops of various arms in defense reform was considered in the article. Determine the status of development of physical and special abilities of military guards 21-30 years.
Volkov V.L.
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Lift Not the Painted Veil! To Whom Are Directors’ Duties Really Owed? [PDF]
, 2015 In this article, we identify a fundamental contradiction in the law of fiduciary duty of corporate directors across jurisdictions, namely the tension between the uniformity of directors’ duties and the heterogeneity of directors themselves.
Gelter, Martin, Helleringer, Geneviève
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Assessing the Fiscal Costs and Benefits of A8 Migration to the UK [PDF]
, 2009 A8 immigrants who are eligible to receive state benefits are 60% less likely to claim for them than the native population -- and are 13% less likely to do so adjusting for demographics.
Caroline Halls +2 more
core
[Dilemmas and afflictions of duty nurses evidenced in focal group].
Revista da Escola de Enfermagem da U S P, 2010 The aim of this study was to critically reflect on the experiences of duty nurses. The objectives were: to learn how duty nurses described and interpreted their knowledge and experiences about this reality; and to reflect about possible ways to overcome the identified problems. This is a qualitative study using the focal-group technique.
Heloisa Wey, Berti +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source