Results 111 to 120 of about 104,801 (306)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Assessment of physical and special training of border guards to the profession the first age group [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
The problem of managing the physical and special training of troops of various arms in defense reform was considered in the article. Determine the status of development of physical and special abilities of military guards 21-30 years.
Volkov V.L.
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

[Dilemmas and afflictions of duty nurses evidenced in focal group].

Revista da Escola de Enfermagem da U S P, 2010
The aim of this study was to critically reflect on the experiences of duty nurses. The objectives were: to learn how duty nurses described and interpreted their knowledge and experiences about this reality; and to reflect about possible ways to overcome the identified problems. This is a qualitative study using the focal-group technique.
Heloisa Wey, Berti, Jairo Aparecido, Ayres, Maria José dos Reis, Lima, Renata Wey Berti, Mendes   +3 more
openaire   +1 more source

Excise duties in EU

, 2021
Gledajući porezne namete različitih država kroz povijest, trošarine su se nametnule kao jedna od prvih vrsta oporezivanja. Uz izravne poreze koji se prvenstveno odnose na porez na dohodak i porez na dobit, trošarine pripadaju kategoriji neizravnih ...
Miholić-Galic, Matija
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Human erroranalysis among petrochemical plant control room operators with human errorassessment and reduction technique

Salāmat-i kār-i Īrān, 2009
Background and aims Control room is a palpitating heart of a system, and any error in operator`s duties have irreparable consequences. Nowadays, in many work places such as nuclear industry, military and chemical parts human error can cause catastrophic ...
S. Varmazyar, SB. Mortazavi, H. Asilian, M. Ghalenoei   +3 more
doaj  

Level and limitations of physical activity in patients with excess body weight or diabetes

BMJ Open Sport & Exercise Medicine
Physical activity (PA) is recommended to prevent or treat many diseases, but various factors may limit it. We analyse the level of PA and the barriers to undertaking it.
Edyta Sutkowska, Karolina Biernat, Justyna Mazurek, Katarzyna Hap, Natalia Kuciel, Magdalena Sutkowska, Dominik Marciniak   +6 more
doaj   +1 more source

Bus crew scheduling using mathematical programming [PDF]

, 1986
This thesis describes a bus crew scheduling system, IMPACS, which has been demonstrated to be successful for a wide variety of scheduling conditions, and is at present in regular use by three British bus companies including the largest, London Buses Ltd.
Smith, Barbara Mary
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source