Results 91 to 100 of about 94,048 (263)

Level and limitations of physical activity in patients with excess body weight or diabetes

BMJ Open Sport & Exercise Medicine
Physical activity (PA) is recommended to prevent or treat many diseases, but various factors may limit it. We analyse the level of PA and the barriers to undertaking it.
Edyta Sutkowska, Karolina Biernat, Justyna Mazurek, Katarzyna Hap, Natalia Kuciel, Magdalena Sutkowska, Dominik Marciniak   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

[Dilemmas and afflictions of duty nurses evidenced in focal group].

Revista da Escola de Enfermagem da U S P, 2010
The aim of this study was to critically reflect on the experiences of duty nurses. The objectives were: to learn how duty nurses described and interpreted their knowledge and experiences about this reality; and to reflect about possible ways to overcome the identified problems. This is a qualitative study using the focal-group technique.
Heloisa Wey, Berti, Jairo Aparecido, Ayres, Maria José dos Reis, Lima, Renata Wey Berti, Mendes   +3 more
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Distribution of sleep components while working remotely

International Journal of Occupational Medicine and Environmental Health
Objectives The circadian system is the main regulator of almost all human physiological processes. The aim of this study was to assess sleep in the working population, in relation to the share of remote working. Material and Methods An online survey was
Magdalena Janc, Agnieszka Jankowska, Zbigniew Jozwiak, Teresa Makowiec-Dabrowska, Joanna Jurewicz, Kinga Polanska   +5 more
doaj   +1 more source

Estimating the differential exposure of household groups to alcohol duty reforms in Great Britain

Journal of Public Health
Abstract Background We explored the potential impact of changes to the UK alcohol tax system implemented in August 2023 on increases on consumer spending, the separate impacts of the changes to the duty structures, and how these impacts vary between households depending on their level of ...
Wilson, L.B., Pryce, R., Leeming, G., Holmes, J., Angus, C.   +4 more
openaire   +4 more sources