Results 91 to 100 of about 1,170,336 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Effect of Mindfulness on the Family Well-Being in Mother who Works as a Nurse

open access: yesIJNP (Indonesian Journal of Nursing Practices), 2019
Background: Mothers who work as nurses are one of the vulnerable groups and are at risk of imbalance of roles in work and family due to multiple roles. The dual role requires working mothers to carry out their duties as mothers and wives at home, while ...
Arni Nur Rahmawati   +2 more
doaj   +1 more source

Ethics of Public Administration in the Administration of Governance in Indonesia [PDF]

open access: yes, 2018
Ethics is an important element which determines the successful implementation of organizations activities and public administration actors. The importance to implement public administration ethics in the Indonesia government bureaucracy was based to the ...
Nawawi, Z. (Zaidan)
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Final Report of the Commission on Presidential Disability and the Twenty-Fifth Amendment [PDF]

open access: yes, 1988
This Report examines the Twenty-Fifth Amendment to identify potential difficulties in presidential succession and makes ...
Bayh, Birch E., Jr.   +4 more
core   +1 more source

State legitimacy and self-defence [PDF]

open access: yes, 2011
In this paper I outline a theory of legitimacy that grounds the state’s right to rule on a natural duty not to harm others. I argue that by refusing to enter the state, anarchists expose those living next to them to the dangers of the state of nature ...
Renzo, Massimo
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Do individual and work-related factors differentiate work participation trajectories before and after vocational rehabilitation?

open access: yesPLoS ONE, 2019
BackgroundUnderstanding diverse labor market trajectories around vocational rehabilitation provides important insight into potential effectiveness of rehabilitation efforts.
Taina Leinonen   +4 more
doaj   +1 more source

Turkey: Temporary Trade Barriers as Resistance to Trade Liberalization with the European Union? [PDF]

open access: yes
Turkey has been an active user of antidumping since the 1990s and more recently added safeguards and countervailing duties to its temporary trade barriers (TTBs). Turkey is a founding member of the World Trade Organization and formed a customs union with
Baybars Karacaovali
core  

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