Results 101 to 110 of about 104,801 (306)

Engagement in actions beyond basic professional duties : measurement and correlates [PDF]

open access: yes, 2019
Objective. The main purpose of the paper was to present the construct of engagement in actions beyond basic professional duties (shortly: beyond-duties engagement) and its measurement with the modified version of the UWES-9 questionnaire.
Tokarz, Aleksandra   +5 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The Principal's Role as a Supervisor in Improving Teacher Professionalism

open access: yesUrwatul Wutsqo
This study looks at how the principal at Persis Integrated Islamic Elementary School in Palu City may improve teacher professionalism as a supervisor. Direct observation and in-depth interviews with the principal and a number of instructors were used to ...
Okky Fadila   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

ETHICore: Ethical Compliance and Oversight Framework for Digital Forensic Readiness

open access: yesInformation
How can organisations be forensically ready? As organisations are bound to be criticised in the digitally developing world, they must ensure that they are forensically ready.
Amr Adel, Ali Ahsan, Claire Davison
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Experience in using new technologies in the organizational and methodical maintenance of discipline "Physical Education" in National Technical University of Ukraine "KPI" [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
The forms of physical education are presented for different educational separations. In researches 400 students took part 1-2 courses to the basic and preparatory group. Students got busy in different educational separations.
Mischuk D.N.   +3 more
doaj  

Citizenship and Membership Duties Toward Quasi-Citizens

open access: yes, 2017
In the 20th century, nation-states became the dominant form of political community around the world. Yet, aided by transportation and communications innovations, many 21st century states are forming regional partnerships; accepting dual or multiple ...
Rogers Smith
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Agency, duties and the "Ashley treatment"

open access: yes, 2009
In 2006, a paper in the journal Archives of Pediatric and Adolescent Medicine described a novel case of growth attenuation therapy and other treatments carried out on Ashley, a severely cognitively, neurologically and physically disabled 6-year-old girl.
Tan, N.   +3 more
core   +1 more source

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