Results 101 to 110 of about 1,170,336 (314)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Influence of Nursing Time and Staffing on Medication Errors: A Cross-Sectional Analysis of Administrative Data

open access: yesNursing Reports
Background: Medication errors cause adverse events; however, studies have yet to examine medication errors related to nursing hours while considering ward characteristics in Japan.
Mutsuko Moriwaki   +5 more
doaj   +1 more source

Prevention and Management Strategies of the Conflict of Interest in the Legal Systems of Iran and Kuwait [PDF]

open access: yesآموزه‌های حقوق کیفری کشورهای اسلامی
Conflict of interest refers to a situation where an individual, organization or institution, due to the existence personal or group interests, is unable to perform their official and legal duties impartially and in the public interest.
Mohammad Ali Haji Dehabadi   +1 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

ETHICore: Ethical Compliance and Oversight Framework for Digital Forensic Readiness

open access: yesInformation
How can organisations be forensically ready? As organisations are bound to be criticised in the digitally developing world, they must ensure that they are forensically ready.
Amr Adel, Ali Ahsan, Claire Davison
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Experience in using new technologies in the organizational and methodical maintenance of discipline "Physical Education" in National Technical University of Ukraine "KPI" [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
The forms of physical education are presented for different educational separations. In researches 400 students took part 1-2 courses to the basic and preparatory group. Students got busy in different educational separations.
Mischuk D.N.   +3 more
doaj  

Challenges to the Takeover Early Warning System in the EU: The Case of Germany

open access: yesCroatian Yearbook of European Law and Policy, 2014
The paper shows the regulation of particular duties of investors and issuers in relation to direct or indirect holdings of publicly listed shares, building together an early warning system indicating an imminent change of control in companies.
Danijel Stanković
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The Duty to Promote Digital Minimalism in Group Agents

open access: yes
AbstractIn this chapter, we turn our attention to the effects of the attention economy on our ability to act autonomously as a group. We begin by clarifying which sorts of groups we are concerned with, which are structured groups (groups sufficiently organized that it makes sense to attribute agency to the group itself).
Timothy Aylsworth, Clinton Castro
openaire   +1 more source

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