Results 81 to 90 of about 104,801 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Settling a conflict of interest in judicial and lawyer activity: general and specific issues (by the example of class proceedings)

Russian Journal of Economics and Law
Objective: to clarify the concept of “conflict of interest”, to identify the peculiarities of conflict of interest resolution in group proceedings, and to develop practical recommendations to prevent conflict of interest in judicial and advocacy ...
O. S. Belosludtsev, I. V. Ginzburg
doaj   +1 more source

Solvency, company directors’ duties and the problem of process and enforcement - A comparative study

, 2011
This study examines the legal provisions in relation to creditors’ protection, particularly when the company is insolvent and seeks to compare different statutory approaches with the view of determining the best reforms for Malaysia.
Mansor, Hariati
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Effect of Mindfulness on the Family Well-Being in Mother who Works as a Nurse

IJNP (Indonesian Journal of Nursing Practices), 2019
Background: Mothers who work as nurses are one of the vulnerable groups and are at risk of imbalance of roles in work and family due to multiple roles. The dual role requires working mothers to carry out their duties as mothers and wives at home, while ...
Arni Nur Rahmawati, Meidiana Dwidiyanti, Muhammad Mu'in   +2 more
doaj   +1 more source

Group Duties. Their Existence and Their Implications for Individuals (Stephanie Collins)

Gogoa, 2019
Betebeharren inguruko hausnarketa filosofikoa zerbait berria ez bada ere, azkenengo urteetan gero eta analisi filosofiko gehiago agertzen eta eztabaidatzen ari dira. Era berean, egungo ontologia sozialak “talde” moduko entitate sozialen ikerketa zaharra tresna sofistikatuagoekin eraberritu du. Erraza da betebeharrak eta entitate sozialak harreman estua
openaire   +2 more sources

Patients’ Duties in the Legal and Ethical Relationship between Patient and a Physician [PDF]

, 2016
Person requiring medical treatment is obliged to do everything possible to enable it. European legal theory considers patients’ duty to comply, as subsidiary contractual obligation, comparing to obligation of fee payment.
Sjeničić, Marta
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source