Results 61 to 70 of about 20,463,524 (267)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Perturbed conformal field theory, nonlinear integral equations and spectral problems [PDF]

, 2000
This thesis is concerned with various aspects of perturbed conformal field theory and the methods used to calculate finite-size effects of integrable quantum field theories.
Dunning, Tania Clare, Tania Clare Dunning, Dunning, T.C.   +2 more
core  

Scattering in Geometric Approach to Quantum Theory

, 2022
We define inclusive scattering matrix in the framework of a geometric approach to quantum field theory. We review the definitions of scattering theory in the algebraic approach and relate them to the definitions in the geometric ...
Albert Schwarz
core   +1 more source

Towards a bootstrap approach to higher orders of epsilon expansion

Journal of High Energy Physics, 2018
We employ a hybrid approach in determining the anomalous dimension and OPE coefficient of higher spin operators in the Wilson-Fisher theory. First we do a large spin analysis for CFT data where we use results obtained from the usual and the Mellin ...
Parijat Dey, Apratim Kaviraj
doaj   +1 more source

T T ¯ , J T ¯ , T J ¯ $$ T\overline{T},J\overline{T},T\overline{J} $$ partition sums from string theory

Journal of High Energy Physics, 2020
We calculate the torus partition sum of a general CFT2 with left and right moving conserved currents J and J ¯ $$ \overline{J} $$ , perturbed by a combination of the irrelevant operators T T ¯ , J T ¯ $$ T\overline{T},J\overline{T} $$ and T J ¯ $$ T ...
Akikazu Hashimoto, David Kutasov
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Statistical predictions from anarchic field theory landscapes [PDF]

, 2010
Consistent coupling of effective field theories with a quantum theory of gravity appears to require bounds on the rank of the gauge group and the amount of matter. We consider landscapes of field theories subject to such to boundedness constraints.
Naqvi, A., de Boer, J., Balasubramanian, V., de Boer, Jan, Balasubramanian, Vijay, Naqvi, Asad   +5 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Antea Group Archeologie 2021/36

, 2021
Antea Group heeft In februari 2021 een archeologisch bureauonderzoek en inventariserend veldonderzoek door middel van boringen uitgevoerd in het kader van de aanleg van een gashogedruk- en een gaslagedrukleiding langs de oostzijde van de Hoofdweg tussen ...
Fens, R. (Antea Group), Fens, R.L. (Antea Group), Fens, R (Antea Group)   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source