Results 41 to 50 of about 1,157 (207)

An Analysis of the Readings of the Language of the Qurʾān and Its Epistemological Sources [PDF]

open access: yesآموزه‌های قرآنی
The language of the Qurʾān is one of the most debated topics in scholarly circles, drawing significant attention from experts in the field. As a matter of fact, their views in this field have not been in a specific trajectory.
Muhamad jawad Tawakuli Khaniki   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

The usage of the accusative without prepositions in modern Croatian language

open access: yesRasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2011
The paper discusses the examples of more frequent usage of accusative without prepositions in contemporary Croatian media and in spoken language. Examples of such usage are classified into several groups: 1.
Vlasta Rišner
doaj  

Fault detection and diagnosis of electric bus air conditioning systems incorporating domain knowledge and probabilistic artificial intelligence

open access: yesEnergy and AI
The air conditioning systems in electric city buses usually operate in rapidly changing ambient conditions and are more likely to suffer from mechanical faults.
Fangzhou Guo, Zhijie Chen, Fu Xiao
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Gülistan Tercümesinde İkili Kullanımlar ve Bu Kullanımların Bugünkü Oğuz ve Kıpçak Lehçelerindeki Görünümü

open access: yesErdem, 2018
Kıpçak Türkçesinin tekedebi eseri durumunda olan Gülistan Tercümesi, İranlı şair Sadi’nin eserinin Seyf-i Sarâyî tarafından 1Eylül 1391 Cuma günü tamamlanmış serbest çevirisidir. Yazıda, GülistanTercümesi’nin ses ve şekil bilgisi özelliklerinde karşımıza
Okan Celal Güngör
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Double accusative cases in old Persian constructions [PDF]

open access: yesزبان پژوهی
Introduction The Old Persian language comprises of seven cases, one of which is the accusative case. This case is used in intransitive, transitive, and ditransitive verbs.
Sahar Vahdati Hosseinian   +3 more
doaj   +1 more source

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