Results 231 to 240 of about 671,076 (285)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

CRISPR-MiX: A pooled single-stranded donor strategy to enhance HDR efficiency in human iPSCs. [PDF]

Mol Ther Nucleic Acids
Baum R, Telugu N, Bruyneel AAN, Kay M, Nair P, Perea-Gil I, Termglinchan V, Bharucha N, Lee E, Mercola M, Diecke S, Karakikes I.   +11 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Identification and genomic characterization of a goose astrovirus in Henan Province, China. [PDF]

Front Vet Sci
Dong W, Lv H, Zhang X, Sheng Y, Wu Q, Li J, Wu Y, Peng Z.   +7 more
europepmc   +1 more source

Probing omics data via harmonic persistent homology. [PDF]

Sci Rep
Gurnari D, Guzmán-Sáenz A, Utro F, Bose A, Basu S, Parida L.   +5 more
europepmc   +1 more source

Identification and functional insights into new phage tail-like bacteriocins targeting <i>Pseudomonas aeruginosa</i> as new antimicrobials. [PDF]

Microbiol Spectr
Ibarguren-Quiles C, Blasco L, López-Causape C, Bleriot I, Fernández-García L, Arman L, Barrio-Pujante A, Ortiz-Cartagena C, Aracil B, Menéndez-Rodriguez O, Mariñas-Pardo L, Cantón R, Oliver A, Tomás M.   +13 more
europepmc   +1 more source

All-natural medicine food homology herb-based self-gelling hemostatic powder for rapid hemostasis and diabetic wound management. [PDF]

J Nanobiotechnology
Zhang M, Peng J, Peng X, Ye T, Qin Q, Deng L, Wang Y, Jiang Y, Liang P.   +8 more
europepmc   +1 more source

Spaces and sequences in the hippocampus: a homological perspective. [PDF]

J Comput Neurosci
Babichev A, Vashin V, Dabaghian Y.
europepmc   +1 more source