Bisimple Inverse Semigroups [PDF]
In [1] Clifford showed that the structure of any bisimple inverse semigroup with identity is uniquely determined by that of its right unit subsemigroup. The object of this paper is to show that the structure of any bisimple inverse semigroup with or without identity is determined by that of any of its a-classes.
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Inverse limits of finite rank free groups [PDF]
Abstract.We will show that the inverse limit of finite rank free groups with surjective connecting homomorphism is isomorphic either to a finite rank free group or to a fixed universal group. In other words, any inverse system of finite rank free groups which is not equivalent to an eventually constant system has the universal group as its limit.
Conner, Gregory R., Kent, Curtis
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Inverse renormalization group based on image super-resolution using deep convolutional networks
The inverse renormalization group is studied based on the image super-resolution using the deep convolutional neural networks. We consider the improved correlation configuration instead of spin configuration for the spin models, such as the two ...
Kenta Shiina +4 more
doaj +1 more source
Reduced group schemes as iterative differential Galois groups
This article is on the inverse Galois problem in Galois theory of linear iterative differential equations in positive characteristic. We show that it has an affirmative answer for reduced algebraic group schemes over any iterative differential field ...
Maurischat, Andreas
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
When unit groups of continuous inverse algebras are regular Lie groups
It is a basic fact in infinite-dimensional Lie theory that the unit group G(A) of a continuous inverse algebra A is a Lie group. We describe criteria ensuring that the Lie group G(A) is regular in Milnor's sense.
Glockner, Helge, Neeb, Karl-Hermann
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
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