Results 131 to 140 of about 780,853 (256)

Nature-Based Health Interventions for People with Mild to Moderate Anxiety, Depression, and/or Stress: Identifying Target Groups, Professionals, Mechanisms, and Outcomes Through a Delphi Study. [PDF]

Int J Environ Res Public Health
Madsen LS, Ryom K, Nielsen LJ, Poulsen DV, Jessen NH.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Precision diagnosis and therapy for pediatric central nervous system tumors: consensus from the Brazilian Society of Pediatric Oncology (SOBOPE). [PDF]

Lancet Reg Health Am
Farias de Alvarenga KA, Oliveira de Araújo J, Rezende da Silveira M, Silva NS, Coelho MR, Pimentel JA, Pereira Dos Reis A, Cappellano AM, Mançano BM, D'Almeida Costa F, Martins FD, Bellas GO, Teixeira GR, Gomy I, Gregianin LJ, Okamoto OK, Campregher PV, Camargo R, Ferman SE, Valera ET, Brazilian Committee of Precision Medicine in Pediatric Oncology (BC-PMPO) — the Brazilian Society of Pediatric Oncology (SOBOPE).   +20 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Observation of practical teaching skills instrument (OPTIn): transforming the way we observe, evaluate and improve physically active teaching strategies. [PDF]

Front Sports Act Living
Lander N, Patterson K, Eather N, Robinson K, Riley N, Lai SK, Weatherell N, Orr J, Salmon J.   +8 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Exploration of the clinical exercise physiologist standards in the UK: are they fit for purpose and how could they be developed? [PDF]

BMJ Open Sport Exerc Med
Crozier A, Osin C, Sadler I, Graves LEF, Rycroft J, Dawson E, Miller G, Green DJ, Naylor L, Askew CD, Jones H.   +10 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Development of an optimal pathway for endoscopic sleeve gastroplasty implementation in the NHS: a modified nominal group technique study. [PDF]

BMJ Open Gastroenterol
Currie A, O'Neill F, Hayee B, Bansi D, Parmar C, McBride E, Fernando K, Grimes L, Vijayaraman A, Mahawar K, Allan C, Dhar A, Clare K, Pournaras DJ, Parretti HM, Kelly J.   +15 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source