Results 71 to 80 of about 708,548 (296)

Leveraging Community‐Based System Dynamics to Understand Long Covid Disparities in African American Communities: A Model for Health Equity Research

Health Expectations
Background Long Covid disproportionately affects African American communities, exacerbating pre‐existing health disparities and systemic barriers to care.
Chad R. Evans, Melvin R. Echols, D. Martin Jr., H. A. Taylor, James A. Washington II, Olusola Gbinigie, Anne H. Gaglioti, Wendi Wright, Peter Hovmand   +8 more
doaj   +1 more source

Understanding food insecurity in England: a systems-based approach

Policy Design and Practice
Food insecurity is a significant public health issue in England. National and local policies have not been able to adequately address its complex drivers, in part due to unintended consequences that arise from the way these policies interact with the ...
Charan Bijlani, Denise Ndlovu, Dianna Smith, Claire Thompson, Leandro Garcia, Cornelia Junghans, Eszter P. Vamos, Paraskevi Seferidi   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Systems modelling as an approach for understanding and building consensus on non-communicable diseases (NCD) management in Cambodia

BMC Health Services Research, 2019
Background This paper aims to demonstrate how systems modeling methodology of Group Model Building (GMD) can be applied for exploring and reaching consensus on non-communicable disease (NCD) management.
John P. Ansah, Amina Mahmood Islam, Victoria Koh, Vanthy Ly, Hero Kol, David B. Matchar, Chhun Loun, Mondol Loun   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Group-dependent finite mixture model

, 2021
We present a Bayesian nonparametric group-dependent mixture model for clustering. This is achieved by building a hierarchical structure, where the discreteness of the shared base measure is exploited to cluster the data, between and within groups.
Argiento, Raffaele
core   +2 more sources

Building a Shared Model for Multi-criteria Group Decision Making

, 2017
Shared procedures to build a consensus within a group decision process are sometimes used in multi-criteria decision-making. Facilitators often face several challenges and the solutions to overcome them are scarce and not well documented.
Marleau Donais, Francis, Abi-Zeid, Irène, Irène Abi-Zeid, Roxane Lavoie, Francis Marleau Donais, Lavoie, Roxane   +5 more
core   +1 more source

Comparison of LiDAR Building Point Cloud with Reference Model for Deep Comprehension of Cloud Structure

, 2020
This paper studies the fidelity level of the extracted LiDAR (Light Detection And Ranging) building point cloud in relation to the original building. In this context, the building point cloud is compared with a reference model.
Tarsha Kurdi, Fayez, Fayez Tarsha Kurdi, Mohammad Awrangjeb, Awrangjeb, Mohammad   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Where to Start? Participatory Systems Mapping for Place-Based Service Integration in the City of Casey

Systems
Place-based approaches have gained significant attention as a means of addressing entrenched disadvantage through collaborative, locally responsive service delivery, yet implementation has yielded mixed results and the systemic factors that facilitate or
Matt Healey, Joseph Lea, Vanessa Hammond
doaj   +1 more source