Results 91 to 100 of about 24,815,163 (243)

Energy Efficiency and Building Codes Working Group meeting minutes

, 2009
Application/pdf. "The Energy Efficiency Building Codes Working Group, which was established in 2009, is no longer active... The Working Group held several meetings in 2009 and 2010 and endorsed an approach that encouraged voluntary adoption by local ...
Kansas. Energy Efficiency and Building Codes Working Group.
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Eclectic flavor group ∆(27) ⋊ S 3 and lepton model building

Journal of High Energy Physics
We have performed a systematical study of the eclectic flavor group ∆(27) ⋊ S 3 which is the extension of the traditional flavor symmetry ∆(27) by the finite modular symmetry S 3.
Cai-Chang Li, Gui-Jun Ding
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Experiences testing enhanced building performance simulation prototypes on potential user group [PDF]

, 2009
Previous work involving literature review, simulation tool analysis and interviews with world leading building performance consulting engineers and designers has shown that building performance simulation (BPS) is mostly limited to code compliance ...
Hopfe, C.J., Hensen, J.L.M., Hopfe, CJ Christina, Hensen, JLM Jan   +3 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A systems thinking framework for understanding rising childhood obesity in the Caribbean

Health Research Policy and Systems
Objective The aim of this study is to develop a systems thinking framework to describe the common complexities of childhood obesity in the Caribbean region and identify potential areas of intervention.
Leonor Guariguata, Amy Burlar, Natalie Greaves, Heather Harewood, Raveed Khan, Rosa V. Rosario-Rosado, Waneisha Jones, Brita Roy, Saria Hassan   +8 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Computational Fluid Dynamics simulations of wind-driven rain on a low-rise building : new validation efforts [PDF]

, 2005
Despite the establishment of CFD as a tool for calculating the amount of wind-driven rain (WDR) falling onto building facades, very few efforts have been made towards the validation of CFD for this purpose.
Blocken, B.J.E., Carmeliet, J., Blocken, BJE Bert, Carmeliet, JE Jan   +3 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source