Results 111 to 120 of about 5,835,473 (292)

PyR@TE: Renormalization Group Equations for General Gauge Theories

, 2013
Although the two-loop renormalization group equations for a general gauge field theory have been known for quite some time, deriving them for specific models has often been difficult in practice.
Lyonnet, Florian, Schienbein, Ingo, Staub, Florian, Wingerter, Akin   +3 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Engaging communities, modeling systems: lessons from system dynamics modeling on maternal health in Texas

Frontiers in Global Women's Health
IntroductionDisparate maternal health outcomes among non-Hispanic Black women stem from intricate, interrelated factors shaped by clinical, social, and structural influences.
Kyrah K. Brown, Michael K. Lemke, Deneen Robinson, Saeideh Fallah-Fini, David W. Lounsbury, David W. Lounsbury, Thanayi Lambert, Mercy J. Obasanya, Tiffany B. Kindratt   +8 more
doaj   +1 more source

Optimal sequential fingerprinting: Wald vs. Tardos

, 2015
We study sequential collusion-resistant fingerprinting, where the fingerprinting code is generated in advance but accusations may be made between rounds, and show that in this setting both the dynamic Tardos scheme and schemes building upon Wald's ...
Chernoff H., Ibrahimi S., Jennison C., Mukhopadhyay N., Oosterwijk J.-J., Oosterwijk J.-J., Siegmund D., Wald A., Wetherill G. B.   +8 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Impact of Group Model Building on Behavior [PDF]

, 2016
Contains fulltext : 178390pub.pdf (Publisher’s version ) (Open Access) Contains fulltext : 178390pos.pdf (Author’s version postprint ) (Open Access)
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A CONTRIBUTION TO THE DEBATE ON SCIENCE AND FAITH BY CHRISTIAN STUDENTS FROM ABIDJAN

Zygon, 2017
The science and faith debate is dominated by Western voices. In order to enrich this debate, the authors study the discourses of different groups of Christian academics and master's students in francophone Africa.
doaj   +2 more sources