Results 131 to 140 of about 5,835,473 (292)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Understanding key drivers of performance in the provision of maternal health services in eastern cape, South Africa: a systems analysis using group model building

BMC Health Services Research, 2018
BackgroundThe Eastern Cape Province reports among the poorest health service indicators in South Africa with some of its districts standing out as worst performing as regards maternal health indicators.
Martina Lembani, H. de Pinho, P. Delobelle, Christina Zarowsky, Thubelihle Mathole, A. Ager   +5 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Systematic Investigations of the Free Fermionic Heterotic String Gauge Group Statistics: Layer 1 Results

, 2011
Using software under development at Baylor University, we explicitly construct all layer 1 gauge, weakly coupled free fermionic heterotic string models up to order 22 in four large space-time dimensions.
Buescher, C., Cleaver, G., Greenwald, J., Janas, M., Miller, G., Moore, D., Renner, T., Robinson, M., Ruhnau, S.   +8 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A systems thinking framework for understanding rising childhood obesity in the Caribbean

Health Research Policy and Systems
Objective The aim of this study is to develop a systems thinking framework to describe the common complexities of childhood obesity in the Caribbean region and identify potential areas of intervention.
Leonor Guariguata, Amy Burlar, Natalie Greaves, Heather Harewood, Raveed Khan, Rosa V. Rosario-Rosado, Waneisha Jones, Brita Roy, Saria Hassan   +8 more
doaj   +1 more source

Renormalization Group Invariants in the MSSM and Its Extensions

, 2005
We derive one-loop renormalization group (RG) invariant observables and analyze their phenomenological implications in the MSSM and its \mu problem solving extensions, U(1)' model and NMSSM.
, A.E. Nelson, A.E. Nelson, B.C. Allanach, D.A. Demir, Durmus A Demir, K. Inoue, K. Inoue, N. Arkani-Hamed, S. Minwalla, S.A. Abel, V. Jain   +11 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Expert insights into public health nutrition challenges: a rapid group model building demonstration workshop

Public Health Nutrition
Objective: This paper explored international experts’ views on what influences the development and implementation of local government (LG) planning policy to support healthy food retail environments; and 2) whether a rapid group model building (RGMB ...
Cindy Needham, Penny Fraser, Carmen Vargas, Laura Alston, Steven Allender   +4 more
doaj   +1 more source