Results 141 to 150 of about 5,835,473 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Patterns of systemic problems in Ghana's poultry value chain: A group model building approach

open access: yesJournal of Agriculture and Food Research
Ghana's poultry sector faces different interrelated systemic challenges, often diagnosed in isolation, leading to interventions that neglect unintended consequences across the value chain.
Joshua Aboah   +5 more
doaj   +1 more source

Reverse engineering in construction [PDF]

open access: yes, 2003
Recently a great deal of research into construction IT has been completed, and this is ongoing to improve efficiency and quality in the construction sector.
Arayici, Y, Hamilton, A, Hunter, G
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Understanding the dynamics of implementing the Norwegian School Fruit Programme: integrating implementation science and system dynamics

open access: yesImplementation Science Communications
Background Many implementation determinants of school nutritional interventions have been identified, but a deeper understanding of their interplay within a system is needed. The present study aimed to investigate how the Norwegian School Fruit Programme,
Mahshid Zolfaghari   +6 more
doaj   +1 more source

Anatomy of $\varepsilon'/\varepsilon$ beyond the Standard Model

open access: yes, 2019
We present for the first time a model-independent anatomy of the ratio $\varepsilon'/\varepsilon$ in the context of the $\Delta S = 1$ effective theory with operators invariant under QCD and QED and in the context of the Standard Model Effective Field ...
Aebischer, Jason   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Resolutions of C^n/Z_n Orbifolds, their U(1) Bundles, and Applications to String Model Building

open access: yes, 2007
We describe blowups of C^n/Z_n orbifolds as complex line bundles over CP^{n-1}. We construct some gauge bundles on these resolutions. Apart from the standard embedding, we describe U(1) bundles and an SU(n-1) bundle.
A. Wulzer   +24 more
core   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Heavy Hitters and the Structure of Local Privacy

open access: yes, 2017
We present a new locally differentially private algorithm for the heavy hitters problem which achieves optimal worst-case error as a function of all standardly considered parameters. Prior work obtained error rates which depend optimally on the number of
Alon N.   +4 more
core   +1 more source

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