Results 141 to 150 of about 708,548 (296)

Strengthening the System Supporting Perinatal People with Substance Use Disorder in the Midwest Using Group Model Building. [PDF]

Matern Child Health J, 2023
Simon J, Guynn I, Thompson M, Hambright S, Jones C, Lich KH.   +5 more
europepmc   +1 more source

Group model building as mutual persuasion [PDF]

, 2003
Contains fulltext : 218392.pdf (Publisher’s version ) (Open Access)
openaire  

Building Performance Simulation for Sustainable Energy Use in Buildings

, 2010
This paper aims to provide a general view of the background and current state of building performance simulation, which has the potential to deliver, directly or indirectly, substantial benefits to building stakeholders and to the environment.
Hensen, J.L.M., Hensen, JLM Jan
core  

Group model building effectiveness: a review of assessment studies

, 2002
Contains fulltext : 74885.pdf (Publisher’s version ) (Open Access)Abstract Over the last decades system dynamicists have experimented with approaches to achieve more involvement of their clients in the model building process.
Rouwette, E.A.J.A., Vennix, J.A.M., Mullekom, T.L. van   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Planning, implementing and governing systems-based co-creation: the DISCOVER framework

Health Research Policy and Systems
Background Increasingly, public health faces challenges requiring complex, multifaceted and multi-sectoral responses. This calls for systems-based approaches that facilitate the kind of collective and collaborative thinking and working required to ...
Niamh Smith, Michail Georgiou, Mohammad S. Jalali, Sebastien Chastin   +3 more
doaj   +1 more source

A causal loop diagram of older persons' emergency department visits and interactions of its contributing factors: a group model building approach. [PDF]

Eur Geriatr Med, 2023
Smeekes OS, Willems HC, Blomberg I, Buurman BM.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Adolescents' Perspectives on the Drivers of Obesity Using a Group Model Building Approach: A South African Perspective. [PDF]

Int J Environ Res Public Health, 2022
Hendricks G, Savona N, Aguiar A, Alaba O, Booley S, Malczyk S, Nwosu E, Knai C, Rutter H, Klepp KI, Harbron J.   +10 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source