Results 121 to 130 of about 5,835,473 (292)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
The HIRM+ Flight Dynamics Model [PDF]
, 2002 The major objective of the GARTEUR Action Group on Analysis Techniques for Clearance of Flight Control Laws FM(AG-11) is the improvement of the flight clearance process by increased automation of the tools used for modelbased analysis of the aircraft’s ...
Moormann, D.
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Risk Management and Healthcare PolicyTingting Qin, Xingming Li, Kun Qiao, Xinyuan Bai, Mingyu Gu, Yao Wang School of Public Health, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Xingming Li, School of Public Health, Capital Medical University, No.
Qin T, Li X, Qiao K, Bai X, Gu M, Wang Y
doaj
Investigating system-level drivers of obesity with adolescents: a group model-building exercise
The Lancet, 2019 Background Capturing voices of young people on issues that affect them is crucial for developing effective, relevant public health policies. We report the use of group model building with young people to identify their views on drivers of adolescent ...
N. Savona, C. Knai, T. Macauley
semanticscholar +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Interdisciplinary knowledge integration through group model building
, 2010 sponsorship: The research for this article was executed as part of the NeWater project (Contract no 511179 6th EU Framework Programme) The authors would like to thank the European Commission for the financial support received and the NeWater consortium members for their kind collaboration (EU|511179, European Commission)
Hovelynck, Johan +3 more
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Health ExpectationsBackground Most studies on older adults' vitality focus on linear connections between determinants and outcomes. To design more comprehensive and impactful approaches to support the vitality of older adults, a better understanding of the interplay among ...
Djoeke Besselink +7 more
doaj +1 more source
Systems research and behavioral science, 2018 Sugar‐sweetened beverage tax (SSB tax) has been proposed in Thailand in an attempt to reduce sugar content in beverages and sugar consumption among the Thai population.
Nipaporn Urwannachotima +2 more
semanticscholar +1 more source