Results 121 to 130 of about 24,815,163 (243)

Planning, implementing and governing systems-based co-creation: the DISCOVER framework

Health Research Policy and Systems
Background Increasingly, public health faces challenges requiring complex, multifaceted and multi-sectoral responses. This calls for systems-based approaches that facilitate the kind of collective and collaborative thinking and working required to ...
Niamh Smith, Michail Georgiou, Mohammad S. Jalali, Sebastien Chastin   +3 more
doaj   +1 more source

Application of group model building in implementation research: A systematic review of the public health and healthcare literature. [PDF]

PLoS One, 2023
Estrada-Magbanua WM, Huang TT, Lounsbury DW, Zito P, Iftikhar P, El-Bassel N, Gilbert L, Wu E, Lee BY, Mateu-Gelabert P, S Sabounchi N.   +10 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

High performance building envelopes with retro-reflective materials

, 2017
Highly reflective materials have been proposed as a strategy for energy consumption reduction in buildings and outdoor comfort improvement (i.e. urban heat island mitigation).
CASTELLANI, BEATRICE, ROSSI, Federico, MORINI, ELENA, PRESCIUTTI, ANDREA, COTANA, Franco   +4 more
core  

Strengthening the System Supporting Perinatal People with Substance Use Disorder in the Midwest Using Group Model Building. [PDF]

Matern Child Health J, 2023
Simon J, Guynn I, Thompson M, Hambright S, Jones C, Lich KH.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A causal loop diagram of older persons' emergency department visits and interactions of its contributing factors: a group model building approach. [PDF]

Eur Geriatr Med, 2023
Smeekes OS, Willems HC, Blomberg I, Buurman BM.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Applying participatory systems approaches to enhance child mental health in local communities in Denmark: a process evaluation

Health Research Policy and Systems
Background Group model building (GMB) based on systems approaches is increasingly used to facilitate a shared understanding of complex problems, structures and relationships.
K. Ryom, I.-M. Graversen, H. Kirkegaard, S. Allender, H. T. Maindal, P. Bentsen, A.-L. Bjerregaard, J. N. Østergaard, T. L. Petersen   +8 more
doaj   +1 more source