Results 101 to 110 of about 708,548 (296)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The impact of group model building on behaviour
, 2017 Group model building refers to a process of building system dynamics models with decision makers, experts, and other stakeholders. Involving stakeholders in building system dynamics models has a long history going back several decades (Andersen, Vennix ...
Malpass, J. +3 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Health ExpectationsBackground Most studies on older adults' vitality focus on linear connections between determinants and outcomes. To design more comprehensive and impactful approaches to support the vitality of older adults, a better understanding of the interplay among ...
Djoeke Besselink +7 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Can involving clients in simulation studies help them solve their future problems? A transfer of learning experiment [PDF]
, 2015 It is often stated that involving the client in operational research studies increases conceptual learning about a system which can then be applied repeatedly to other, similar, systems.
Robinson, Stewart +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Eclectic flavor group ∆(27) ⋊ S 3 and lepton model building
Journal of High Energy PhysicsWe have performed a systematical study of the eclectic flavor group ∆(27) ⋊ S 3 which is the extension of the traditional flavor symmetry ∆(27) by the finite modular symmetry S 3.
Cai-Chang Li, Gui-Jun Ding
doaj +1 more source
Using a group decision support system to add value to group model building
, 2010 This note intends to contribute to the practice of group model building by presenting group model-building scripts that can (1) create a preliminary problem boundary using less than one hour of group time, (2) convene discussions with the group that ...
Fran Ackermann +10 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source