Results 151 to 160 of about 708,548 (296)

Qualitative modelling of social determinants of health using group model building: the case of debt, poverty, and health. [PDF]

Int J Equity Health, 2022
Reumers L, Bekker M, Hilderink H, Jansen M, Helderman JK, Ruwaard D.   +5 more
europepmc   +1 more source

Reviewing the Role of Stakeholders in Operational Research: Opportunities for Group Model Building [PDF]

, 2013
Contains fulltext : 116929pre.pdf (Author’s version preprint ) (Open Access)Stakeholders have always received much attention in system dynamics, especially in the group model building tradition, which emphasizes the deep involvement of ...
Kranenburg, H.L. van, Gooyert, V. de, Rouwette, E.A.J.A.   +2 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing the impact of amended building regulations on the operations of UK construction companies

, 2008
The UK government continues to make regular amendments to building regulations. This is in order to keep these regulations relevant to today’s prevailing construction environment. More recently, UK building regulations have been amended to facilitate the
Ojiako, Udechukwu, Hughes, Lawrence, Dawson, Richard   +2 more
core  

Aspects of model building in noncommutaive quantum field theories [PDF]

, 2004
We review quantum field theories on noncommutative Minkowski spaces (NCQFTs), concentrating on the mixing between ultra-violet and infra-red degrees of freedom in such theories.
Levell, Jonathan
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Applying participatory systems approaches to enhance child mental health in local communities in Denmark: a process evaluation

Health Research Policy and Systems
Background Group model building (GMB) based on systems approaches is increasingly used to facilitate a shared understanding of complex problems, structures and relationships.
K. Ryom, I.-M. Graversen, H. Kirkegaard, S. Allender, H. T. Maindal, P. Bentsen, A.-L. Bjerregaard, J. N. Østergaard, T. L. Petersen   +8 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Using group model building to frame the commercial determinants of dietary behaviour in adolescence - proposed methods for online system mapping workshops. [PDF]

BMC Med Res Methodol, 2022
Chavez-Ugalde Y, Toumpakari Z, White M, De Vocht F, Jago R.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source