Results 161 to 170 of about 708,548 (296)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Beyond Policy: Strengthening District Level Access to Surgery Is Critical to Achieving Surgical Equity in Universal Health Coverage Comment on "Improving Access to Surgery Through Surgical Team Mentoring - Policy Lessons From Group Model Building With Local Stakeholders in Malawi". [PDF]

Int J Health Policy Manag, 2023
Henry JA.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Planning, implementing, and evaluating an online group-model-building workshop during the COVID-19 pandemic: celebrating successes and learning from shortcomings. [PDF]

Syst Dyn Rev, 2022
Brown KK, Lemke MK, Fallah-Fini S, Hall A, Obasanya M.   +4 more
europepmc   +1 more source

Capacity building towards sustainability: Context of post disaster waste management

Concept of Capacity Building is an essential component in development theory and practice. In developing countries, it is identified as a key concept in achieving sustainability. In particular, in post disaster scenarios, focus has been placed upon local
Amaratunga, Dilanthi, Haigh, Richard, Karunasena, G. I.   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A technical review of BIM based cost estimating in UK quantity surveying practice, standards and tools

, 2014
In light of recent technological advancements over the decades especially with Information Technology (IT), the ‘Building Information Modelling’ (BIM) is one of those advancements that have attracted significant attentions in UK construction industry ...
Wood, Gerard, Wood, GD, Jong, SW, Ginige, Kanchana, Turk Ž, Jong, Siaw Wee, Wood, G, Ginige, K, Wu, Song, Kanchana Ginige Dr, Song Wu Prof, Wu, S, Gerard Wood Dr   +12 more
core  

Development of Evaluation Model for Building Energy Usage: Methodology Development and Case Study on Day-Care Centers in South Korea

This study proposes a methodology for fairly assessing the building energy usage level of occupants using a public open dataset. A case study of day-care centers in South Korea was conducted to demonstrate the methodology.
Chan-Hyuk Mo, Abu Talib, Kwangwon Choi, Jinhyung Park, Deuk-Woo Kim, Jaewan Joe, Semi Park   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source