Results 41 to 50 of about 2,169,177 (303)
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Drugs in R&D, 2020 Background and Objectives Currently, there are no US FDA-approved therapies for eosinophilic esophagitis (EoE). Budesonide oral suspension (BOS; SHP621, TAK-721) is a viscous, muco-adherent, oral formulation of budesonide that is in phase III development
Ivy H. Song +2 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Aquafed - another pressure group for private water [PDF]
, 2006 An analysis of the new private water lobby group, Aquafed, and the other forms of lobbying and pressure used by the private water ...
Hall, David, Hoedeman, Olivier
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Adaptation of the performance control system of a technological piston hydrogen compressor to unstable operating conditions [PDF]
Омский научный вестник: Серия "Авиационно-ракетное и энергетическое машиностроение"Issues related to possible problems of the feasibility of operating the existing system for regulating the performance of a technological piston hydrogen compressor at a large chemical production and the relevance of its modernization are considered ...
V. L. Yusha +3 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2020 Gene therapy product release requires reliable and consistent demonstration of biopotency. In hemophilia B vectors, this is usually determined in vivo by measuring the plasma levels of the expressed human factor IX (FIX) transgene product in FIX knockout
Johannes Lengler +8 more
doaj +1 more source
Stainless steels reinforced with intermetallics useful against corrosion and wear [PDF]
, 2008 Powder Technology Research Group has developed an innovative family of composite materials is presented. Metallic matrix are austenitic and ferritic stainless steels, and as reinforcements, intermetallics, have been used in quantities from 1% to 15% (vol.
Torralba Castelló, José Manuel
core +1 more source
Diversification in the international construction business [PDF]
, 2017 Economic globalization has created an interdependent market that allows companies to transcend traditional national boundaries to conduct business overseas. In the international construction market, companies often adopt diversification as a strategy for
Flanagan, Roger +3 more
core +2 more sources