Results 131 to 140 of about 2,160,854 (336)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Study on Distribution Law of Vertical Earth Pressure on the Top of High-Fill Box Culvert in Gully Terrain Under Expanded Polystyrene Board Unloading

open access: yesApplied Sciences
This study quantifies vertical earth pressure on the roofs of box culverts under high fills in valley terrain using centrifuge model tests with expanded polystyrene (EPS) geofoam for load mitigation.
Conglin Guo   +5 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Research on Spraying Quality Prediction Algorithm for Automated Robot Spraying Based on KHPO-ELM Neural Network

open access: yesMachines
In the intelligent transformation of spraying operations, the investigation into the robotic spraying process holds significant importance. The spraying process, however, falls within the realm of experience-driven technology, characterized by high ...
Le Ling   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Strength Characteristics of DMJ Piles Based on Indoor Tests

open access: yesInfrastructures
The Deep Cement Mixing Integrated Drilling, Mixing and Jetting (DMJ) method represents a novel approach to the construction of slurry piles in the Yellow River Floodplain, offering the potential to enhance the quality of these structures.
Hongzhi Yue   +10 more
doaj   +1 more source

Hermitian K-theory for stable $\\infty$-categories III: Grothendieck-Witt\n groups of rings [PDF]

open access: green, 2020
Baptiste Calmès   +8 more
openalex   +1 more source

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