Results 101 to 110 of about 298,852 (261)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC

Frontiers in Oncology
BackgroundImmune checkpoint inhibitors (ICIs) have improved outcomes in advanced non-small cell lung cancer (NSCLC), but clinical benefit remains heterogeneous and is not fully explained by programmed death-ligand 1 (PD-L1) expression or tumour ...
Pedro Gonzalez Santa-Catalina, Pedro Gonzalez Santa-Catalina, Luis Posado-Domínguez, Luis Posado-Domínguez, Álvaro López-Gutiérrez, Álvaro López-Gutiérrez, Edel del Barco Morillo, Edel del Barco Morillo, Edel del Barco Morillo, Edel del Barco Morillo, Juan Carlos Redondo-González, Juan Carlos Redondo-González, Noelia Egido-Iglesias, Noelia Egido-Iglesias, Laura Corvo-Félix, Laura Corvo-Félix, Isabel Muela Bravo, Isabel Muela Bravo, Aline Rodrigues-Françoso, Aline Rodrigues-Françoso, Lorena Bellido-Hernández, Lorena Bellido-Hernández, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Emilio Fonseca-Sánchez, Emilio Fonseca-Sánchez, Juan Jesús Cruz-Hernández, Juan Manuel Corchado, Juan Manuel Corchado, Juan Manuel Corchado, Juan Manuel Corchado, Juan Manuel Corchado, Juan Luis García Hernández, Juan Luis García Hernández, Alejandro Olivares-Hernández, Alejandro Olivares-Hernández, Alejandro Olivares-Hernández   +36 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Social group signatures in hummingbird displays provide evidence of co-occurrence of vocal and visual learning. [PDF]

Proc Biol Sci, 2019
Araya-Salas M, Smith-Vidaurre G, Mennill DJ, González-Gómez PL, Cahill J, Wright TF.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Somatic mutations of esophageal adenocarcinoma: a comparison between Black and White patients

Scientific Reports
Esophageal adenocarcinoma is the most common histological subtype of esophageal cancer in Western countries and shows poor prognosis with rapid growth. EAC is characterized by a strong male predominance and racial disparity.
Hyeyeun Lim, Marie-Claude Gingras, Jing Zhao, Jinyoung Byun, Patricia D. Castro, Spiridon Tsavachidis, Jianhong Hu, Harshavardhan Doddapaneni, Yi Han, Donna M. Muzny, Richard A. Gibbs, Christopher I. Amos, Aaron P. Thrift   +12 more
doaj   +1 more source

Fine-scale differentiation between Bacillus anthracis and Bacillus cereus group signatures in metagenome shotgun data. [PDF]

PeerJ, 2018
Petit Iii RA, Hogan JM, Ezewudo MN, Joseph SJ, Read TD.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Group-Oriented Ring Signature [PDF]

Journal of Convergence Information Technology, 2011
Chunbo Ma, Jun Ao
openaire   +2 more sources