Results 101 to 110 of about 2,823,093 (309)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Clinical supervisor’s experiences of peer group clinical supervision during COVID-19: a mixed methods study

BMC Nursing
Background Providing positive and supportive environments for nurses and midwives working in ever-changing and complex healthcare services is paramount.
Owen Doody, Kathleen Markey, James Turner, Claire O. Donnell, Louise Murphy   +4 more
doaj   +1 more source

Keefektifan Metode Microskill Untuk Meningkatkan Kualitas Supervisi Klinik

Jurnal Pendidikan Kedokteran Indonesia, 2012
Background: Clinical education requires competent supervisor to guide student. Supervisory competency should be trained and closely monitored to ensure quality learning process taking place.
Sunarko Sunarko, Ova Emilia, Harsono Mardiwiyoto   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Group versus individual supervision of university students: a qualitative study

Dansk Universitetspaedagogisk Tidsskrift, 2019
Background: Studies investigating strengths and limitations of group and individual supervision of university students are sparse. The aims of the present study were to investigate advantages and disadvantages of group and individual supervision, and to ...
janni Niclasen, Pernille Strøbæk
doaj  

Too close for comfort? Politician - interest group relations under voters' supervision [PDF]

This article analyzes the dynamics of electoral promises towards the population and interest groups, focusing on the reaction of voters to the proximity of a candidate to interests groups.
Etienne Farvaque, Gaël Lagadec
core  

PENGELOLAAN SUPERVISI PENDIDIKAN DI SMP KECAMATAN KEDAWUNG KABUPATEN SRAGEN [PDF]

, 2015
Sukardi , Q. 100 130 042. Education Management Supervision In SMP Sub District Kedawung Sragen. Thesis, Education Management, Graduate. Universitas Muhammadiyah Surakarta, September, 2015 . The aim of research 1) To describe the supervision of planning
, Dr. Darsinah, M. Si, , Dr. Suyatmini, M.Si, SUKARDI, SUKARDI   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Capital adequacy regulation of financial conglomerates in the European Union [PDF]

, 2010
Over the past few decades, changes in market conditions such as globalisation and deregulation of financial markets as well as product innovation and technical advancements have induced financial institutions to expand their business activities beyond ...
Yoo, Y. Emilie
core