Results 91 to 100 of about 19,037,056 (340)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Group Theory Analysis to Study Phase Transitions of Quasi-2D Sr3Hf2O7. [PDF]

open access: yesNanomaterials (Basel), 2021
da Silva EL   +8 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Radion-Higgs mixing in 2HDMs

open access: yesJournal of High Energy Physics, 2018
We study the custodial Randall-Sundrum model with two Higgs doublets localized in the TeV brane. The scalar potential is CP- conserving and has a softly broken Z 2 symmetry. In the presence of a curvature-scalar mixing term ξ ab ℛΦ a †Φ b the radion that
Marco Merchand   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Borel-Weil Theory for Root Graded Banach-Lie groups [PDF]

open access: green, 2009
Christoph Mueller   +2 more
openalex   +1 more source

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