Results 81 to 90 of about 914,946 (318)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Renormalization group theory of molecular dynamics. [PDF]

Sci Rep, 2021
Ichishima D, Matsumura Y.
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Electroweak baryogenesis and the standard model effective field theory

Journal of High Energy Physics, 2018
We investigate electroweak baryogenesis within the framework of the Standard Model Effective Field Theory. The Standard Model Lagrangian is supplemented by dimension-six operators that facilitate a strong first-order electroweak phase transition and ...
Jordy de Vries, Marieke Postma, Jorinde van de Vis, Graham White   +3 more
doaj   +1 more source

State-space renormalization group theory of nonequilibrium reaction networks: Exact solutions for hypercubic lattices in arbitrary dimensions. [PDF]

Phys Rev E, 2022
Yu Q, Tu Y.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Group Theory Analysis to Study Phase Transitions of Quasi-2D Sr₃Hf₂O₇. [PDF]

Nanomaterials (Basel), 2021
da Silva EL, Gerami AM, Lekshmi PN, Marcondes ML, Assali LVC, Petrilli HM, Correia JG, Lopes AML, Araújo JP.   +8 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Radion-Higgs mixing in 2HDMs

Journal of High Energy Physics, 2018
We study the custodial Randall-Sundrum model with two Higgs doublets localized in the TeV brane. The scalar potential is CP- conserving and has a softly broken Z 2 symmetry. In the presence of a curvature-scalar mixing term ξ ab ℛΦ a †Φ b the radion that
Marco Merchand, Marc Sher, Keith Thrasher   +2 more
doaj   +1 more source

Generalized group field theories and quantum gravity transition amplitudes [PDF]

, 2006
Daniele Oriti
openalex   +1 more source