Results 161 to 170 of about 1,552,234 (302)

The Consensus Reporting Items for Studies in Primary Care (CRISP) Checklist supports family medicine research in South Korea. [PDF]

Korean J Fam Med
Phillips WR, Sturgiss EA.
europepmc   +1 more source

Crossroads, Connections, and Creativity: Musselman Library Strategic Plan

, 2007
The Musselman Library Strategic Plan grew out of two all-staff meetings held in January 2007. During the first, library staff identified areas of strength and weakness, as well as opportunities for improvement and growth.
Musselman Library,
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Exploring associations of three evaluative subjective wellbeing measures (Cantril's ladder, life satisfaction, happiness) with 15 childhood and demographic factors across 22 countries. [PDF]

Sci Rep
Lomas T, Koga HK, Padgett RN, Pawelski JO, Kim ES, Makridis CA, Gundersen C, Bradshaw M, Pertel NL, Shiba K, Felton C, Helliwell JF, Johnson BR, VanderWeele TJ.   +13 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Assessing Knowledge, Attitude, and Practice of Twin Block Functional Therapy for Angle's Class II Malocclusion Among Postgraduate Students of Pediatric Dentistry in India: A Cross-Sectional Survey. [PDF]

Cureus
Bhattacharjee A, Khanna R, Singh RK, Oberoi A.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Preliminary evaluation of a tailored difficulty index for long-distance family caregivers of older adults with dementia. [PDF]

BMC Geriatr
Falzarano FB, Cimarolli VR, Riffin C, Czaja SJ, Boerner K.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessments, diagnostic criteria and outcome measures for growing pains and persistent pain in the presence of restless leg syndrome in children: a scoping review. [PDF]

BMJ Open
Smith M, Pacey V, Davies LM, Coventry J, Ilhan E, Williams CM.   +5 more
europepmc   +1 more source