Results 51 to 60 of about 128,440 (289)
Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance
eLife, 2018 Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces.
Kentarou Baba +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Phytohormones Regulate Both “Fish Scale” Galls and Cones on Picea koraiensis
Frontiers in Plant Science, 2020 The larch adelgid Adelges laricis laricis Vallot is a specialist insect parasite of Picea koraiensis (Korean spruce) and forms fish scale-like galls that damage the growth of the host plants. Our investigation reveals that both these galls and the fruits
Mingyue Jia +8 more
doaj +1 more source
Disclinations, e-cones, and their interactions in extensible sheets
, 2016 We investigate the nucleation, growth, and spatial organization of topological defects with a ribbon shaped elastic sheet which is stretched and twisted.
Chopin, Julien, Kudrolli, Arshad
core +3 more sources
Predicting Axonal Response to Molecular Gradients with a Computational Model of Filopodial Dynamics [PDF]
, 2004 Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia ...
Caton A. +3 more
core +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Protein synthesis within neuronal growth cones [PDF]
The Journal of Neuroscience, 1992 This study investigates the capacity of neuronal growth cones to synthesize protein locally and independently of their cell body. Isolated growth cones were prepared from cultures of neurons from the snail Helisoma by transecting neurites proximal to the growth cone.
L, Davis, P, Dou, M, DeWit, S B, Kater
openaire +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The nonuniqueness of the tangent cones at infinity of Ricci-flat manifolds
, 2016 It is shown by Colding and Minicozzi the uniqueness of the tangent cone at infinity of Ricci-flat manifolds with Euclidean volume growth which has at least one tangent cone at infinity with a smooth cross section.
Hattori, Kota
core +1 more source
Cytoskeletal dynamics in growth-cone steering [PDF]
Journal of Cell Science, 2009 Interactions between dynamic microtubules and actin filaments are essential to a wide range of cell biological processes including cell division, motility and morphogenesis. In neuronal growth cones, interactions between microtubules and actin filaments in filopodia are necessary for growth cones to make a turn.
Geraldo, Sara, Gordon-Weeks, Phillip R.
openaire +3 more sources