Results 91 to 100 of about 2,220,186 (305)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Skew-Growth Curves [PDF]

Proceedings of the National Academy of Sciences, 1925
R, Pearl, L J, Reed
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The estimation of pubertal growth spurt parameters using the superimposition by translation and rotation model in Korean children and adolescents: a longitudinal cohort study

Frontiers in Pediatrics
ObjectivesUnderstanding the characteristics of the pubertal growth spurt in Korean children and adolescents can serve as crucial foundational data for researching puberty and growth-related disorders.
Dohyun Chun, Dohyun Chun, Seo Jung Kim, Yong Hyuk Kim, Junghwan Suh, Jihun Kim, Jihun Kim   +6 more
doaj   +1 more source

Complementarities, Costly Investment and Multiple Equilibria in a One-Sector Endogenous Growth Model [PDF]

In this paper we develop a multiple equilibria one-sector R&D-based growth model, in which the key aspects are the assumption of complementarities between capital goods in the production function and the assumption of costly investment in capital.
Maria João Ribeiro Thompson
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Acumulación de materia seca y balance de nutrientes en tomate (Solanum lycopersicum L.) cultivado en ambiente protegido

Bioagro
El estudio de absorción de nutrientes es una herramienta que permite a los productores y técnicos de campo afinar los programas de fertilización, al determinar la cantidad de nutrientes demandado por los tejidos de las plantas en las diferentes etapas de
Henrry Gandica Omaña, Haydee Peña
doaj  

Effect of crossbreeding on growth performance, gene expression and Gompertz modelling in meat rabbit under Egyptian environmental conditions

World Rabbit Science
The purpose of this research was to compare the growth performance and gene expression variations in three genetic groups of meat rabbits: Alexandria line (AA), V line (VV) and the cross between Alexandria line males and V line females (AV).
Ghada Abd El-latif, Sarah El-Messeiry, Alaa El-Raffa, Intesar Abu Aliwa, Walid Habashy   +4 more
doaj   +1 more source

The Irrational “War on Inflation”: Why Inflation Targeting is Both Socially Unacceptable and Economically Untenable [PDF]

inflation targeting, war on inflation, social consequences, monetary policy, reserve bank, growth-inflation ...
Graeme Snooks
core