The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders. [PDF]
Endocr Connect, 2018 The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the ...
Blum WF +6 more
europepmc +2 more sources
Tissue-specific and mosaic imprinting defects underlie opposite congenital growth disorders in mice. [PDF]
PLoS Genet, 2018 Differential DNA methylation defects of H19/IGF2 are associated with congenital growth disorders characterized by opposite clinical pictures. Due to structural differences between human and mouse, the mechanisms by which mutations of the H19/IGF2 ...
Freschi A +12 more
europepmc +2 more sources
Adherence and long-term growth outcomes: results from the easypod™ connect observational study (ECOS) in paediatric patients with growth disorders. [PDF]
Endocr Connect, 2018 Objective The easypod connect observational study (ECOS) assessed treatment adherence among paediatric patients receiving growth hormone (GH) via the easypod electronic injection device.
Koledova E +3 more
europepmc +2 more sources
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment
, 2014 The Hair Follicle (HF) is a vital component of mammalian skin and represents a unique, highly regenerative system that undergoes phases of rapid growth, regression, and resting periods. The hair cycling is of profound clinical relevance since majority of
Ines Brajac Marija
openalex +2 more sources
Identification and characterization of nanobodies targeting the EphA4 receptor [PDF]
, 2017 The ephrin receptor A4 (EphA4) is one of the receptors in the ephrin system that plays a pivotal role in a variety of cell-cell interactions, mostly studied during development. In addition, EphA4 has been found to play a role in cancer biology as well as
Chavez-Gutierrez, Lucia +16 more
core +2 more sources
EFFECT OF MIRROR VISUAL FEEDBACK ON HAND FUNCTIONS IN CHILDREN WITH HEMIPARESIS
International Journal of Physiotherapy, 2016 Background: Hemiparetic and hemiplegic cerebral palsy(CP) constitute at least a third of all people with CP. Children with hemiparesis are suffering from weak hand muscles and retarded hand use.Mirror therapy is a relatively new approach in ...
Mohammed Ismael Elsepaee +3 more
doaj +1 more source
Growth disorders among 6-year-old Iranian children. [PDF]
Iran Red Crescent Med J, 2014 Background: Sociodemographic factors are important determinants of weight disorders. National representative studies provide a view on this health problem at national and regional levels.
Kelishadi R +6 more
europepmc +2 more sources
Insulin-like growth factor axis in pregnancies affected by fetal growth disorders. [PDF]
Clin Epigenetics, 2016 BackgroundInsulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal growth.
Nawathe AR +5 more
europepmc +2 more sources
Nutritional status of young children with inherited blood disorders in western Kenya. [PDF]
, 2014 To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6–35 months of age in western Kenya.
Ruth, LJ +4 more
core +1 more source
Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]
, 2020 In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong +15 more
core +1 more source