Health Technology Assessment, 2010 Background: Recombinant human growth hormone (rhGH) is licensed for short stature associated with growth hormone deficiency (GHD), Turner syndrome (TS), Prader–Willi syndrome (PWS), chronic renal insufficiency (CRI), short stature homeobox-containing ...
A Takeda +7 more
doaj +2 more sources
Genetics of Growth Disorders-Which Patients Require Genetic Testing? [PDF]
Front Endocrinol (Lausanne), 2019 The second 360° European Meeting on Growth Hormone Disorders, held in Barcelona, Spain, in June 2017, included a session entitled Pragmatism vs. Curiosity in Genetic Diagnosis of Growth Disorders, which examined current concepts of genetics and growth in
Argente J +3 more
europepmc +2 more sources
Screening for Growth Disorders [PDF]
Journal of Medical Screening, 1994 L D Voss +3 more
openaire +3 more sources
The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders. [PDF]
Endocr Connect, 2018 The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the ...
Blum WF +6 more
europepmc +2 more sources
Tissue-specific and mosaic imprinting defects underlie opposite congenital growth disorders in mice. [PDF]
PLoS Genet, 2018 Differential DNA methylation defects of H19/IGF2 are associated with congenital growth disorders characterized by opposite clinical pictures. Due to structural differences between human and mouse, the mechanisms by which mutations of the H19/IGF2 ...
Freschi A +12 more
europepmc +2 more sources
Adherence and long-term growth outcomes: results from the easypod™ connect observational study (ECOS) in paediatric patients with growth disorders. [PDF]
Endocr Connect, 2018 Objective The easypod connect observational study (ECOS) assessed treatment adherence among paediatric patients receiving growth hormone (GH) via the easypod electronic injection device.
Koledova E +3 more
europepmc +2 more sources
Insulin-like growth factor axis in pregnancies affected by fetal growth disorders. [PDF]
Clin Epigenetics, 2016 BackgroundInsulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins (IGFBPs) are expressed in the placenta and known to regulate fetal growth.
Nawathe AR +5 more
europepmc +2 more sources
A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. [PDF]
, 2017 Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these ...
Corsello G +6 more
core +1 more source
Journal of Translational Medicine, 2023 Background The nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) inflammasome is believed to be a key mediator of neuroinflammation and subsequent secondary brain injury induced by ischemic stroke.
Yuxin Chen +9 more
doaj +1 more source
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. [PDF]
, 2011 There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such as Huntington's disease.
Annett, Geralyn +14 more
core +3 more sources