Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Long run Growth, Convergence and Factor Prices [PDF]
no abstract availableeconomic development an growth ;
Verspagen,Bert
core +1 more source
Providing Vitamin B12, Antibiotic and Unknown Growth Factor Activity for Chick Diets ,
, 1952 Elton L. Johnson
openalex +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Targeting nerve growth factor: an Achilles' heel for tumors? [PDF]
J Immunother CancerRepasky E, Mohammadpour H.
europepmc +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Synergistic Effects of Insulin-like Growth Factor-1 and Platelet-Derived Growth Factor-BB in Tendon Healing. [PDF]
Int J Mol SciRieber J +7 more
europepmc +1 more source
Economic growth as the limiting factor for wildlife conservation [PDF]
The concept of limiting factor includes the lack of welfare factors and the presence of decimating factors. Originally applied to populations and species, the concept may also be applied to wildlife in the aggregate.
Czech, Brian
core +1 more source
Studies on a Growth Factor Present in Polished Rice and Required by Chicks on a Simplified Diet
, 1940 E. L. R. Stokstad +2 more
openalex +1 more source