Results 121 to 130 of about 16,701,675 (216)

A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1

Microbiology Spectrum
A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial ...
Elvira Alanis, Faith Aguilar, Niaz Banaei, Frank B. Dean, Alexa Villarreal, Miguel Alanis, Karen Lozano, James M. Bullard, Yonghong Zhang   +8 more
doaj   +1 more source

Entrepreneurship and Economic Growth: An Investigation into the Relationship between Entrepreneurship and Total Factor Productivity Growth in the EU [PDF]

Endogenous growth theory assigns an important role for entrepreneurship in the process of economic development. This paper sets to formally test the impact of entrepreneurship on economic growth.
Andrzej P. Dabkowski
core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

A versatile gold leaf immunosensor with a novel surface functionalization strategy based on protein L and trastuzumab for HER2 detection

Scientific Reports
Although various sensors specifically developed for target analytes are available, affordable biosensing solutions with broad applicability are limited.
Ivana Kundacina, Silvia Schobesberger, Stefan Kittler, Helena Thumfart, Oliver Spadiut, Peter Ertl, Nikola Ž. Knežević, Vasa Radonic   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Differential-difference equations in economics: on the numerical solution of vintage capital growth models. [PDF]

In this papel, we examine techniques for the analytical and numerical solution of statedependent differential-difference equations. Such equations occur in the continuous time modelling of vintage capital growth models, which form a particularly ...
Licandro, Omar, Paul, Christopher, Boucekkine, Raouf   +2 more
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

On the stray grains in single-crystal Ni-based superalloy by additive manufacturing: formation mechanism and elimination strategy

Journal of Materials Research and Technology
Single-crystal nickel-based superalloys are indispensable for aerospace engine turbine blades due to their superior high-temperature performance. Traditional manufacturing methods are complex and costly, with additional expenses from scrapping damaged ...
Zheyu Yang, Xiaochen Li, Jiaqiang Chang, Zhaoxuan Wu, Yanhong Yang, Zhenbo Zhang   +5 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Use of artificial neural networks for differentiated diagnostics of ischemic and hemorrhagic perinatal affections of central neural system in newborns of different terms of gestation

Acta Biomedica Scientifica, 2013
The article describes neonatal and pediatric neurology researching. Among the causes of childhood disability first place belongs to diseases of the nervous system. Among perinatal brain damage leading place is occupied by cerebrovascular pathology.
O. M. Gerget, D. V. Devyatykh, I. V. Mikhalenko   +2 more
doaj