Results 191 to 200 of about 16,701,675 (216)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

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Dissociation of the 7S-nerve growth factor complex in solution

Biochemistry, 1977
Sedimentation and gel-filtration studies of mouse submandibular gland 7S-nerve growth factor (NGF) reveal that this complex dissociates to yield its components at concentrations much higher than those required to exhibit biological activity. Results further indicate that the alpha and gamma protein c omponents of the 7S-NGF complex probably play no ...
N J, Pantazis, R A, Murphy, J D, Saide, M H, Blanchard, M, Young   +4 more
openaire   +2 more sources

Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor

Journal of Molecular Biology, 2002
Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mediator of angiogenesis and vasculogenesis. VEGF is involved pathologically in cancer, proliferative retinopathy and rheumatoid arthritis, and as such represents an important therapeutic target. Three classes of disulfide-constrained peptides that antagonize binding of the
Borlan, Pan, Bing, Li, Stephen J, Russell, Jeffrey Y K, Tom, Andrea G, Cochran, Wayne J, Fairbrother   +5 more
openaire   +2 more sources

Active Conformations of Glycosaminoglycans. NMR Determination of the Conformation of Heparin Sequences Complexed with Antithrombin and Fibroblast Growth Factors in Solution

Seminars in Thrombosis and Hemostasis, 2002
Binding to proteins usually induces perturbation of nuclear magnetic resonances of ligand molecules. Using sensitive nuclear magnetic resonance (NMR) spectroscopy techniques, these perturbations have been measured for heparin oligosaccharides in aqueous solution in the presence of proteins and the NMR data have been used to characterize the three ...
Milos, Hricovíni, Marco, Guerrini, Antonella, Bisio, Giangiacomo, Torri, Annamaria, Naggi, Benito, Casu   +5 more
openaire   +2 more sources

Structural analysis of vascular endothelial growth factor receptor‐2/ligand complexes by small‐angle X‐ray solution scattering

The FASEB Journal, 2011
ABSTRACT Receptor tyrosine kinases play essential roles in tissue development and homeostasis, and aberrant signaling by these molecules is the basis of many diseases. Understanding the activation mechanism of these receptors is thus of high clinical relevance.
Kisko Kaisa, Brozzo Maurice S, Missimer John, Schleier Thomas, Menzel Andreas, Leppänen Veli-Matti, Alitalo Kari, Walzthoeni Thomas, Aebersold Ruedi, Ballmer-Hofer Kurt   +9 more
openaire   +5 more sources

Systemic Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Stage and Metastatic Breast Cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Özge Gümüşay, Laura A Huppert   +2 more
exaly  

Picturing the Growth Order of Solutions in Complex Linear Differential–Difference Equations With Coefficients of φ-Order

Axioms, 2023
Luis Manuel Sánchez Ruiz, Nityagopal Biswas, Sanjib Kumar Datta   +2 more
exaly  

Better Solutions Needed to Reduce Suicides Among Patients With Cancer

Ca-A Cancer Journal for Clinicians, 2023
Mike Fillon
exaly  

Description of Growth and Oscillation of Solutions of Complex Lde’s

Journal of the Australian Mathematical Society, 2023
Igor Elbertovych Chyzhykov, Janne Gröhn, Janne Mikael Heittokangas   +2 more
exaly  

Epigenetic Epidemiology of Complex Diseases Using Twins

Medical Epigenetics, 2013
Qihua Tan
exaly