Results 301 to 310 of about 2,000,472 (360)

Statins decreases vascular epithelial growth factor (VEGF) expression in experimental age-related macular degradation (AMD) model by down-regulation of receptor for advanced glycation end-products (RAGE)

open access: green, 2017
Hiroki Tsujinaka   +9 more
openalex   +1 more source

Epidermal growth factor receptors

Molecular and Cellular Biochemistry, 1981
EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
E D, Adamson, A R, Rees
openaire   +2 more sources

Keratinocyte Growth Factor Receptors

Dermatologic Clinics, 2007
Modulation of the number of functional growth factor receptors on the epithelial cell surface that is exposed to the action of cognate ligands represents a key strategy in cellular physiology to regulate the proliferation rate and the differentiation process. The keratinocyte growth factor receptor (KGFR) and the epidermal growth factor receptor (EGFR),
Vincenzo de Giorgi   +4 more
openaire   +3 more sources

Hematopoietic growth factor receptors

The International Journal of Cell Cloning, 1991
The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
M F, Brizzi, G C, Avanzi, L, Pegoraro
openaire   +2 more sources

Hematopoietic growth factor receptors

Cytotechnology, 1989
The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive ...
J H, Shieh, M A, Moore
openaire   +2 more sources

Growth factors and their receptors

Current Opinion in Cell Biology, 1989
The growth of cells in culture is controlled by polypeptide hormones that stimulate or inhibit proliferation. More than 20 different growth factors have been extensively characterised, and the corresponding cDNAs have been cloned (Table 1). Several additional growth factors are known from their biological activities but have not yet been structurally ...
B, Westermark, C H, Heldin
openaire   +2 more sources

Epidermal Growth Factor Receptor Mutations

Thoracic Surgery Clinics, 2020
Up to 20% of lung adenocarcinomas in the United States and Europe and 50% in Asia have activating mutations of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). The identification and subsequent targeting of mutations with EGFR-tyrosine kinase inhibitors (TKIs) led to significant advances in treatment of EGFR-mutant lung cancer.
Erin M, McLoughlin, Ryan D, Gentzler
openaire   +2 more sources

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