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Ellagic Acid and Its Nanoparticles Mitigate Atherosclerosis by Elevating Low-Density Lipoprotein Receptor Levels Through Targeting of the Epidermal Growth Factor Receptor. [PDF]
Li GT +6 more
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Human epidermal growth factor receptor 2 overexpression is associated with high-grade tumors in upper tract urothelial carcinoma. [PDF]
Huang L, He J.
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Prediction of brain metastasis in patients with epidermal growth factor receptor-positive lung adenocarcinoma based on lung computed tomography-derived radiomics features. [PDF]
Zhang J +6 more
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Epidermal growth factor receptors
Molecular and Cellular Biochemistry, 1981EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
E D, Adamson, A R, Rees
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Keratinocyte Growth Factor Receptors
Dermatologic Clinics, 2007Modulation of the number of functional growth factor receptors on the epithelial cell surface that is exposed to the action of cognate ligands represents a key strategy in cellular physiology to regulate the proliferation rate and the differentiation process. The keratinocyte growth factor receptor (KGFR) and the epidermal growth factor receptor (EGFR),
Vincenzo de Giorgi +4 more
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Hematopoietic growth factor receptors
The International Journal of Cell Cloning, 1991The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
M F, Brizzi, G C, Avanzi, L, Pegoraro
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Hematopoietic growth factor receptors
Cytotechnology, 1989The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive ...
J H, Shieh, M A, Moore
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Growth factors and their receptors
Current Opinion in Cell Biology, 1989The growth of cells in culture is controlled by polypeptide hormones that stimulate or inhibit proliferation. More than 20 different growth factors have been extensively characterised, and the corresponding cDNAs have been cloned (Table 1). Several additional growth factors are known from their biological activities but have not yet been structurally ...
B, Westermark, C H, Heldin
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Epidermal Growth Factor Receptor Mutations
Thoracic Surgery Clinics, 2020Up to 20% of lung adenocarcinomas in the United States and Europe and 50% in Asia have activating mutations of the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). The identification and subsequent targeting of mutations with EGFR-tyrosine kinase inhibitors (TKIs) led to significant advances in treatment of EGFR-mutant lung cancer.
Erin M, McLoughlin, Ryan D, Gentzler
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