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Growth factors and their receptors
Current Opinion in Cell Biology, 1989The growth of cells in culture is controlled by polypeptide hormones that stimulate or inhibit proliferation. More than 20 different growth factors have been extensively characterised, and the corresponding cDNAs have been cloned (Table 1). Several additional growth factors are known from their biological activities but have not yet been structurally ...
B. Westermark, Carl-Henrik Heldin
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Growth Factors and Their Receptors
Hematology/Oncology Clinics of North America, 1994Breast cancer represents a type of malignancy that is amenable to therapy targeting growth factors and receptors. There is considerable evidence that signaling mechanisms involving growth factors and their receptors are important in the normal development of breast epithelium.
Debasish Tripathy, Christopher C. Benz
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Growth Factor Receptors: The Epidermal Growth Factor Receptor as a Model [PDF]
, 1990 Secreted polypeptide growth factors such as insulin, insulinlike growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and colony-stimulating factor (CSF-1) initiate complex cytoplasmic and nuclear events. These distinct cellular responses can be attributed to the interaction of hormones with their respective ...
G. Carpenter +2 more
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Keratinocyte Growth Factor Receptors
Dermatologic Clinics, 2007Modulation of the number of functional growth factor receptors on the epithelial cell surface that is exposed to the action of cognate ligands represents a key strategy in cellular physiology to regulate the proliferation rate and the differentiation process. The keratinocyte growth factor receptor (KGFR) and the epidermal growth factor receptor (EGFR),
Vincenzo de Giorgi +4 more
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Fibroblast growth factors and their receptors
Biochemistry and Cell Biology, 1997Fibroblast growth factors (FGFs) represent a group of polypeptide mitogens eliciting a wide variety of responses depending upon the target cell type. The knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. The complexity of the FGF family and the FGF-induced responses is reflected in the diversity and
John A. Smith +2 more
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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
John T Gallagher, Jacqueline C Coutts
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Epidermal growth factor receptors
Molecular and Cellular Biochemistry, 1981EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
Eileen D. Adamson, Anthony R. Rees
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Growth factor receptors and their ligands
Journal of Neuro-Oncology, 1994The understanding of the signal transduction cascade involving growth factors and their receptors is one major key for diagnostic and therapeutic improvements in human neoplasms. Using receptor autoradiography, an inverse relationship for the incidence of somatostatin receptors (SSR) and epidermal growth factor receptors (EGFR) was found in gliomas [1].
H Mueller, U Eppenberger
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Endocytosis of growth factor receptors
BioEssays, 1993AbstractBinding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptorâmediated endocytosis, a process which involves clathrinâcoated pits.
Alexander Sorkin, Christopher M. Waters
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Hematopoietic growth factor receptors
The International Journal of Cell Cloning, 1991The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
Luigi Pegoraro +2 more
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