Results 1 to 10 of about 987,989 (255)
Growth hormone releasing hormone or growth hormone treatment in growth hormone insufficiency? [PDF]
Archives of Disease in Childhood, 1988 Sixteen prepubertal children who were insufficient for growth hormone were treated with growth hormone releasing hormone (GHRH) 1-40 and GHRH 1-29 for a mean time of nine months (range 6-12 months) with each peptide. Eleven children received GHRH 1-40 in four subcutaneous nocturnal pulses (dose 4-8 micrograms/kg/day) and eight (three of whom were also ...
P J, Smith, C G, Brook
openaire +2 more sources
Growth Hormone Releasing Hormone and Growth Hormone: Genetic Studies in Familial Growth Hormone Deficiency [PDF]
Pediatric Research, 1985 Four families with growth hormone (GH) deficiency, either isolated or with other pituitary hormonal deficits are described. Members of each underwent pharmacological testing for GH secretion and infusions of GH releasing hormone (GHRH) to determine the locus of the defect in GH secretion.
A D, Rogol +6 more
openaire +2 more sources
Growth hormone outgrows growth [PDF]
Clinical Endocrinology, 2004 Growth hormone (GH) replacement has been offered to GH-deficient (GHD) children for approximately 40 years whereas it has only been a licensed indication for the treatment of GHD adults since 1996. Nonetheless, the advent of GH replacement for adult GHD patients (Jorgensen et al., 1989; Salomon et al., 1989) has proved informative about the overall ...
openaire +2 more sources
Growth hormone in growth hormone deficiency [PDF]
BMJ, 2002 Papers p 70 With the advent of an unlimited supply of recombinant DNA growth hormonesome 15 years ago endocrinologists and paediatricians hoped that the majorgoal in treating children with growth hormone deficiency—that is, a near normal adult height—would finally be achievable.
+6 more sources
TREATMENT OF GROWTH-HORMONE DEFICIENCY WITH GROWTH-HORMONE-RELEASING HORMONE
The Lancet, 1987 18 prepubertal growth-hormone (GH)-deficient children were treated with twice-daily subcutaneous injections of a growth-hormone-releasing hormone analogue, GHRH (1-29) NH2. In 12 of the children the height velocity rose on GHRH treatment, and 8 were judged to have shown a worthwhile response to therapy in that their height velocities during the first 6
Ross, R.J.M. +8 more
openaire +3 more sources
Growth-hormone-releasing hormone
Clinical Chemistry, 1990 Abstract Growth-hormone-releasing hormone (GHRH, somatoliberin) is the hypothalamic peptide hormone that specifically stimulates synthesis and release of growth hormone (GH, somatotropin) by somatotrope cells of the anterior pituitary gland.
openaire +2 more sources
Growth Hormone Deficiency [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1987 Growth hormone deficiency is relative, not absolute. Conventional stimulation tests of hGH release do not recognise some children who will benefit from hGH treatment and it is probably justified, at this point, undertaking a six month trial of hGH in all short children who are growing slowly (less than 4 cm/yr).
openaire +4 more sources
Pediatric Clinics of North America, 1997 Growth hormone insensitivity (GHI) may be primary, caused by defects in the GH receptor, or further along the GH-insulin-like growth factor-I (IGF-I) axis, or secondary, resulting from a variety of illnesses or malnutrition affecting various steps in the pathway from the GH binding to IGF-I action.
Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida (ALR) ( host institution ) +3 more
openaire +3 more sources
Diabetes, 1959 THE recent isolation of human growth hormone from pituitary glands collected at autopsy has been of major importance in the investigation of human pituitary physiology.1 , 2 Metabolic studies have confirmed the remarkable anabolic and growth-promoting actions of this hormone in man,3 , 4 in contrast to the negative or equivocal clinical results ...
openaire +2 more sources
Diagnostic Value of Peak-to-Basal Difference or Ratio of Growth Hormone in Children with Growth Hormone Deficiency [PDF]
J Clin Res Pediatr EndocrinolKöprülü Ö +6 more
europepmc +1 more source