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Evolving growth hormone deficiency: proof of concept
Frontiers in EndocrinologyIntroductionWe present the evolution of GHD in adolescent males with persistent growth failure, in whom the diagnosis was established after a second GH stimulation test (GST).MethodsWe performed a retrospective chart review of children who presented for ...
Sri Nikhita Chimatapu +6 more
doaj +1 more source
Pharmacological Research, 2023 We evaluated the efficacy, safety, adherence, quality of life (QoL) and cost-effectiveness of long-acting growth hormone (LAGH) vs daily growth hormone (GH) preparations in the treatment of growth hormone deficiency (GHD) in children. Systematic searches
Chiara Mameli +11 more
doaj
Reported shoes size during GH therapy: is foot overgrowth a myth or reality?
Archives of Endocrinology and Metabolism, 2015 Objectives To describe population reference values for shoes size, and to identify possible disproportional foot growth during GH therapy.Materials and methods Construction of percentile chart based on 3,651 controls (male: 1,838; female: 1,813).
Débora C. F. Lago +3 more
doaj +1 more source
Making sense o fhormone-mediated defense networking: from rice to Arabidopsis [PDF]
, 2014 Phytohormones are not only essential for plant growth and development but also play central roles in triggering the plant immune signaling network. Historically, research aimed at elucidating the defense-associated role of hormones has tended to focus on
De Vleesschauwer, David +2 more
core +3 more sources
Growth in growth hormone insensitivity
Trends in Endocrinology & Metabolism, 1994 Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean.
The Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32608, USA ( host institution ) +4 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Purification and cultivation of human pituitary growth hormone secreting cells [PDF]
A multiphase study was conducted to examine the properties of growth hormone cells. Topics investigated included: (1) to determine if growth hormone (GH) cells contained within the rat pituitary gland can be separated from the other hormone producing ...
Hymer, W. C.
core +1 more source
LC-MS characterization and cell-binding properties of chelate modified somatropin [PDF]
, 2010 Somatropin, a recombinant protein containing 191 amino acids, is derived from the endogenous human growth hormone, somatotropin. This protein is clinically used in children and adults with inadequate endogenous growth hormone to stimulate a normal bone ...
De Spiegeleer, Bart +4 more
core
High Sensitivity Mass Spectrometric Quantification of Serum Growth Hormone by Amphiphilic Peptide Conjugation [PDF]
, 2012 Amphiphilic peptide conjugation affords a significant increase in sensitivity with protein quantification by electrospray-ionization mass spectrometry.
Arsene +25 more
core +1 more source
Growth Hormone & IGF Research, 2016 Once thought to be present only in liver, muscle and adipose tissue, the GH receptor is now known to be ubiquitously distributed, in accord with the many pleiotropic actions of GH. These include the regulation of metabolism, postnatal growth, cognition, immune, cardiac and renal systems and gut function.
openaire +5 more sources