Results 81 to 90 of about 5,571,602 (257)

The effects of Growth hormone treatment discontinuation in Adults on Metabolic profile, Body composition and quality Of Life (GAMBOL Study) [version 2; peer review: 1 approved, 2 approved with reservations]

NIHR Open Research
Background In adults, treatment of GHD with daily GH injection has been shown to improve many clinical features associated with GHD. Currently, many adults with GHD receive GH treatment indefinitely.
Niki Karavitaki, Sherwin Criseno, Anne Topping   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Growth hormone and ageing

, 2000
The proportion of elderly people is steadily growing in Western societies. The result is a disproportionate accumulation of the oldest and most vulnerable sector of the population, suffering from frailty-associated disorders and cardiovascular diseases ...
Bengtsson, B A, Svensson, J, Johannsson, Gudmundur,   +2 more
core  

Growth Hormone and Metabolic Homeostasis

European Medical Journal Diabetes, 2018
Pituitary growth hormone (GH) is a peptide hormone predominantly secreted by somatotrophs in the anterior pituitary under the tight control of the hypothalamic–pituitary axis and GH secretagogues.
Rajkishor Nishad, Dhanunjay Mukhi, Dhanunjay Mukhi, Ram K. Menon   +3 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.

, 2005
Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role.
Segerlantz, Mikael, Groop, Leif, Bramnert, Margareta, Bramnert, Margareta,, Segerlantz, Mikael,, Lund University., Groop, Leif,   +6 more
core   +2 more sources

Growth hormone deficiency and cerebral palsy

Therapeutics and Clinical Risk Management, 2010
Jesús Devesa1,2, Nerea Casteleiro2, Cristina Rodicio2, Natalia López2, Pedro Reimunde1,21Department of Physiology, School of Medicine of Santiago de Compostela, Spain; 2Medical Center Proyecto Foltra, 15886 Teo, SpainAbstract ...
Jesús Devesa, Nerea Casteleiro, Cristina Rodicio, et al   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Growth hormone : basic and clinical aspects /

, 1987
Proceedings of the 1st Nordisk insulin symposium Growth hormone: basic and clinical aspects Stockholm, Sweden, 29 June-1 July ...
Nordisk insulin symposium Growth hormone: basic and clinical aspects1st29 June-1 Juli 1987Stockholm, Sweden, Isaksson, Olle,edt   +1 more
core  

Influence of insulin on growth hormone secretion, level and growth hormone signalling

, 2017
Growth hormone (GH), as a vital hormone, has to experience a series of processes to fulfill its function including secretion, entering the circulation to reach target tissues (pre-receptor process), binding on the GH receptor (GHR) and triggering ...
Qiu, H, Chen, C, Yang, JK
core   +1 more source