Results 211 to 220 of about 761,204 (307)

Dissociation of stimulatory effects of cortocotrophin on adrenal corticosterone and protein synthesis following hypophysectomy [PDF]

, 1968
Kluge, F., Scriba, Peter Christian
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Long-term safety of childhood growth hormone treatment: evidences from real-world study and future directions. [PDF]

World J Pediatr
Zhang C, Liang Y, Luo XP.
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Heightism, growth hormone treatment, and social functioning: a holistic approach to a persistent clinical challenge. [PDF]

Curr Opin Pediatr
Kamoun C, Largent EA, Grimberg A.
europepmc   +1 more source

Functional annotation of ESR1 gene fusions in estrogen receptor-positive breast cancer [PDF]

, 2018
Crowder, Robert, Davies, Sherri R, et al,, Hoog, Jeremy, Iglesia, Michael, Li, Shunqiang, Ma, Cynthia X, Maher, Christopher A, Phommaly, Chanpheng, Rogers, Anna, Shao, Jieya, Watson, Mark A, Zhang, Jin   +12 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Growth hormone treatment in children with Prader-Willi syndrome: safety and effectiveness data from the PATRO Children study. [PDF]

Ther Adv Endocrinol Metab
Lämmer C, Backeljauw P, Tauber M, Kanumakala S, Loche S, Otfried Schwab K, Pfäffle R, Höybye C, Lundberg E, Dahlgren J, Ek AE, Battelino T, Kriström B, Esmael A, Zabransky M.   +14 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

<italic>IGF1</italic> Haploinsufficiency: Phenotype and Response to Growth Hormone Treatment in 9 Patients. [PDF]

Horm Res Paediatr
Joustra SD, Punt LD, van der Kaay DCM, van Setten PA, de Groote K, Kruijsen AR, Bocca G, de Munnik SA, Renes JS, de Bruin C, Losekoot M, van Duyvenvoorde HA, Wit JM, Joustra SD.   +13 more
europepmc   +1 more source