Results 51 to 60 of about 451,544 (302)

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Response to Growth Hormone Treatment in Isolated Growth Hormone Deficiency versus Multiple Pituitary Hormone Deficiency [PDF]

, 2021
Background: Growth hormone (GH) therapy successfully increases height prognosis in children with GH deficiency (GHD); however, adult height data are still limited. Aim: This study investigated near-adult height (NAH) in patients with idiopathic GHD (i.e.
Darendeliler, Fatma Feyza, Lindberg, A., Wilton, P.   +2 more
core   +1 more source

Growth hormone-releasing hormone in the diagnosis and treatment of growth hormone deficient children

Acta Endocrinologica, 1986
ABSTRACT A growth hormone-releasing hormone (GHRH) has recently been extracted and synthesised, and appears to be identical to human hypothalamic GHRH. Immunoreactive GHRH is found in the venous blood of normal subjects and GH-deficient children, but is probably not hypothalamic in origin and therefore not important in GH regulation ...
Ross, R, Grossman, A, Besser, G, Savage, M   +3 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The exon3-deleted growth hormone receptor gene polymorphism (d3-GHR) is associated with insulin and spontaneous growth in short SGA children (NESGAS) [PDF]

, 2017
Objective The effect of a common polymorphism in the Growth Hormone (GH) receptor (d3-GHR) gene on growth, metabolism and body composition was examined in short children born small for gestational age (SGA) on GH treatment.
Thankamony, Ajay, Dunger, David B., Mathilde Gersel Wegmann, Roche, Edna,, Ivarsson, Sten A., Roche, E, Ajay Thankamony, Hoey, Hilary,, Kirk, Jeremy, Ivarsson, Sten-A., Thankamony, A, Rikke Beck Jensen, Jeremy Kirk, Thankamony, Ajay,, Roche, Edna, Juul, Anders,, Söder, Olle, Jensen, Rikke Beck,, Wegmann, Mathilde Gersel, David B. Dunger, Ivarsson, Sten A.,, Ivarsson, Sten-A, Soder, O, Jensen, Rikke Beck, Juul, A, Guftar Shaikh, Söder, Olle,, Edna Roche, Hoey, Hilary, Hoey, H, Kirk, J, Dunger, DB, Kirk, Jeremy,, Dunger, David B, Sten-A. Ivarsson, Anders Juul, Ivarsson, S-A, Wegmann, MG, Hilary Hoey, Juul, Anders, Shaikh, Guftar, Wegmann, Mathilde Gersel,, Dunger, David B.,, Shaikh, Guftar,, Lund University., Shaikh, G, Olle Söder   +46 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Early cessation and non-response are important and possibly related problems in growth hormone therapy: An OZGROW analysis [PDF]

, 2016
Objective: To investigate growth hormone (GH) treatment and treatment cessation with respect to efficacy and efficiency. To identify factors that best classify or predict cessation type: completed treatment (CT), early cessation (EC), or non-response (NR)
Harris, M., Cutfield, W., Cotterill, A, Hughes, IP, Hughes, I., Harris, M, Rath, S, Cutfield, Wayne, Choong, C., Cotterill, A., Rath, S., Choong, C, Hofman, Paul, Atkinson, Helen, Hofman, P., Atkinson, H   +15 more
core   +1 more source

The influence of growth hormone deficiency on bone health and metabolism [PDF]

, 2023
Growth hormone (GH) is a key peptide hormone in the regulation of bone metabolism, through its systemic and paracrine action mediated directly as well as by insulin-like growth factor-1 (IGF-1).
Jakub Wydra, Wojciech Zgliczyński, Arnika Wydra, Izabella Czajka-Oraniec   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source