Results 21 to 30 of about 892,121 (262)

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

open access: yesNeural Regeneration Research, 2022
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease.
Heba M Mansour   +3 more
doaj   +1 more source

Reguladores vegetais no desenvolvimento e produtividade da cana-de-açúcar Growth regulators in the development and productivity of sugarcane

open access: yesPesquisa Agropecuária Brasileira, 2008
O objetivo deste trabalho foi avaliar o desenvolvimento e a produtividade de colmos de cana-de-açúcar, resultantes da aplicação de reguladores vegetais no iníco da safra.
Glauber Henrique Pereira Leite   +1 more
doaj   +1 more source

Plant growth regulators in poplar clones differing in resistance to the fungus Ceratocystis fimbriata Ell. et Haist

open access: yesActa Societatis Botanicorum Poloniae, 2014
In poplar clones with different resistance to the fungus Ceratocystis fimbriata growth of shoots, intensity of transpiration and the level of endogenous growth regulators were determined. More resistant clones, Populus 'Robusta' and P.
Jadwiga Stopińska
doaj   +1 more source

Pathophysiological mechanisms of cardiotoxicity in chemotherapeutic agents

open access: yesRussian Open Medical Journal, 2020
Certain success has been achieved in the treatment of cancer due to the development of various effective chemotherapeutic drugs. However, an increase in their effectiveness (aggressiveness) was associated with a growth of undesirable effects on the ...
Aleksey M. Chaulin   +2 more
doaj   +1 more source

Interspecific differences between D. pulex and D. magna in tolerance to cyanobacteria with protease inhibitors. [PDF]

open access: yesPLoS ONE, 2013
It is known that cyanobacteria negatively affect herbivores due to their production of toxins such as protease inhibitors. In the present study we investigated potential interspecific differences between two major herbivores, Daphnia magna and Daphnia ...
Christian J Kuster, Eric Von Elert
doaj   +1 more source

Nephrotoxicity induced by vascular endothelial growth factor inhibitors [PDF]

open access: yesJournal of Nephropharmacology, 2022
Vascular endothelial growth factor (VEGF) is a special mitogen for vascular endothelial cells, an essential endogenous angiogenic cytokine, and the principal controller of vascular growth that plays a fundamental role in therapeutic angiogenesis pathways.
Shirinsadat Badri   +5 more
doaj   +1 more source

Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.

open access: yesPLoS ONE, 2016
High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of ...
Michael K Kiessling   +8 more
doaj   +1 more source

Fibroblast Growth Factor Inhibitors [PDF]

open access: yesJournal of Thoracic Oncology, 2010
Dr. Ignatio Witsuba (MD Anderson) started this session by giving an overview of the fibroblast growth factor (FGF) pathway and expression of FGFs (22 members), FGF receptors (FGFRs, four members), and their gene family members in non-small cell lung cancer (NSCLC).
openaire   +2 more sources

Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials

open access: yesTechnology in Cancer Research & Treatment, 2020
Background: The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors ...
Yi-Tian Qi MM   +2 more
doaj   +1 more source

Risk factors for thromboembolism during first-line treatment of patients with unresectable advanced or recurrent colorectal cancer: a retrospective short study

open access: yesJournal of Pharmaceutical Health Care and Sciences, 2023
Background While cancer is a risk factor for developing thromboembolism, so is the use of molecularly targeted therapies. This study aimed to determine whether thromboembolism incidence differed between vascular endothelial growth factor (VEGF) and ...
Ryo Takada   +4 more
doaj   +1 more source

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