Results 41 to 50 of about 892,121 (262)

Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. [PDF]

PLoS ONE, 2009
Cyclin-dependent kinases (CDKs) play important roles in regulating cell cycle progression, and altered cell cycles resulting from over-expression or abnormal activation of CDKs observed in many human cancers.
Jing Xiang, Hongbo Yang, Chao Che, Haixia Zou, Hanshuo Yang, Yuquan Wei, Junmin Quan, Hui Zhang, Zhen Yang, Shuo Lin   +9 more
doaj   +1 more source

Steroid Growth Requirements and Steroid Growth Inhibitors of Mycoplasma [PDF]

Journal of General Microbiology, 1960
SUMMARY: Mycoplasma laidlawii strain A did not grow significantly and sometimes died in a peptone + yeast extract (PY) medium; good growth was obtained when 1% serum or 1% bovine plasma albumin was added. The addition of cholesterol and some other steroids (at 20 μg./ml.) to the basal PY medium gave some growth although less than that given by adding ...
M, BUTLER, B C, KNIGHT
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Targeting mTOR for cancer therapy

Journal of Hematology & Oncology, 2019
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2).
Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo, Yangfu Jiang   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The effect of treatment of tubers with Chlorprofam on the keeping quality, biochemical parameters and suitability of potatoes for processing

Овощи России
Relevance. Potatoes are not only the most useful food product, both in its raw form and in its processed products, but they are also valuable technical raw materials, and therefore there is a need to increase the shelf life of tubers and preserve their ...
V. N. Zeyruk, S. V. Vasilieva, G. L. Belov, S. V. Maltsev   +3 more
doaj   +1 more source

Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.

PLoS ONE, 2017
Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene.
Jiaoyuan Jia, Yu Qiao, Maria G Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Shao, Diego F Calvisi, Xin Chen   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source