Results 101 to 110 of about 934,379 (291)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Non-isothermal model for the direct isotropic/smectic-A liquid crystalline transition

, 2009
An extension to a high-order model for the direct isotropic/smectic-A liquid crystalline phase transition was derived to take into account thermal effects including anisotropic thermal diffusion and latent heat of phase-ordering.
Abukhdeir N., Abukhdeir N. M., Amundson K. R., Balluffi R., Barbero G., Bechhoefer J., Bechhoefer J., Bechhoefer J., Benmouna F., Benmouna F., Borrajo J., Brand H. R., Bronnikov S., Bronnikov S., Chan H., Coles H. J., Coles H. J., Coriell S., Das S., de Gennes P., Dierking I., Dierking I., Dorgan J. R., Drzaic P. S., Gomes O. A., González-Cinca R., Graca M., Harrison D., Hoppe C., Hoppe C. E., Hoppe C. E., Huisman B. A. H., Ignés-Mullol J., Lucchetti L., Marinelli M., Mesquita O., Misbah C., Mukherjee P. K., Mukherjee P. K., Mullins W. W., Mullins W. W., Nakazawa H., Oswald P., Oswald P., Oswald P., Oweimreen G. A., Pestov S., Qian T., Rey A., Rey A. D., Rondelez F., Simon A. J., Singh S., Soulé E. R., Soulé E. R., Stewart I., Sutton A., Tokita M., Tokita M., Toledano J.-C., Tuckerman L. S., Yan J., Zammit U., Ziabicki A.   +63 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Prevalence of carbapenemase-producing Klebsiella pneumoniae isolates in Belarus and their competitive ability [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
Susceptibility to antibiotics was determined for 208 hospital isolates from 4 regions of Belarus. The broad abundance of resistance to carbapenems was shown.
Tapalskiy D.V., Petrenyov D.R.
doaj  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Interface stability of particle growth under the influence of nonlinear interface kinetics

工程科学学报, 2016
A mathematical model of particle growth taking nonlinear temperature-depended interface kinetics into account was investigated,and the particle interface evolution and morphological stability were analyzed.
WANG Xin-feng, CHEN Ming-wen, WANG Fei
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

Advanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo, Shuo Qu, Shiming Gao, Xu Song   +3 more
wiley   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source