Results 131 to 140 of about 1,817,169 (352)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Sensitivity analysis of the add-on price estimate for the silicon web growth process [PDF]
The web growth process, a silicon-sheet technology option, developed for the flat plate solar array (FSA) project, was examined. Base case data for the technical and cost parameters for the technical and commercial readiness phase of the FSA project are ...
Mokashi, A. R.
core +1 more source
The Role of Matrix Gla Protein in Ossification and Recovery of the Avian Growth Plate [PDF]
, 2012 Harel Dan +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Design of anisotropic plates for improved damage tolerance [PDF]
An analytical study is presented showing the effects of the notch tip geometry on the location and direction of crack growth from an existing notch in a unidirectional fibrous composite modeled as a homogeneous, anisotropic, elastic material. Anisotropic
Guerdal, Zafer
core +1 more source
Enhancement of cartilage repair through the addition of growth plate chondrocytes in an immature skeleton animal model [PDF]
, 2019 Ryszard Tomaszewski +2 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Non-linear evolution of a second mode wave in supersonic boundary layers [PDF]
The nonlinear time evolution of a second mode instability in a Mach 4.5 wall-bounded flow is computed by solving the full compressible, time-dependent Navier-Stokes equations.
Erlebacher, Gordon, Hussaini, M. Y.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Fracture study of windshield glass panes [PDF]
The major stresses which cause crack propagation in windshield glass panes are induced by bending moments which result from the pressure differentials across the panes.
Yeh, H. Y.
core +1 more source