Results 61 to 70 of about 1,208,663 (362)
Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova +25 morewiley +1 more sourceGenotype, sex and interaction effect on lamb growth traits [PDF]
Biotechnology in Animal Husbandry, 2015 The pure breeds and crossing have an important role in production. It is essential in sheep meat production to maintain the genetic diversity of the adapted breeds, pure breeds and their crosses.Petrović V.C., Petrović M.P., Ružić-Muslić D., Maksimović N., Selionova M.I., Aybazov M.M., Malyukova M.A. +6 moredoaj Hundreds of variants clustered in genomic loci and biological pathways affect human height [PDF]
, 2010 Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits ...A Johansson, A Superti-Furga, Aila Rissanen, Aki S. Havulinna, Alan F. Wright, Alan R. Sanders, Alan R. Shuldiner, Albert Hofman, Albert Vernon Smith, Alessandro De Grandi, Alex N. Parker, Alice M. Arnold, Alistair S. Hall, Ana Marusic, Anders Hamsten, Andrea Maschio, Andreas Ziegler, Andres Metspalu, Andrew A. Hicks, Andrew C. Heath, Andrew P. Morris, Andrew R. Wood, Andrew T. Hattersley, André G. Uitterlinden, Anke Tönjes, Anna Dominiczak, Anna L. Dixon, Anna-Liisa Hartikainen, Anne U. Jackson, Anneli Pouta, Anthony J. Balmforth, Antonella Mulas, Antti Jula, Arthur W. Musk, Astrid Petersmann, AV Segrè, Ayellet V. Segrè, B Devlin, Barbara McKnight, Ben Oostra, Benjamin F. Voight, Brenda W. Penninx, Cameron Palmer, Carlo Rivolta, Carlos Iribarren, Caroline Hayward, Caroline S. Fox, Carsten Oliver Schmidt, CD Campbell, Cecilia M. Lindgren, Charles C. White, Christian Gieger, Christian Hengstenberg, Christopher J. O’Donnell, Claes Ohlsson, Constance Chen, Cornelia M. van Duijn, Cristen J. Willer, Dale R. Nyholt, Daniel Gudbjartsson, Daniel I. Chasman, Daniele Cusi, David J. Hunter, David P. Strachan, David S. Siscovick, David Schlessinger, Dawn Waterworth, DB Goldstein, Devin Absher, DF Gudbjartsson, Dominique J. Verlaan, Dorret I. Boomsma, Douglas F. Levinson, Eco J. C. Geus, Eero Kajantie, Eleanor Wheeler, Elin Grundberg, Elisabeth Widen, Elizabeth K. Speliotes, Elizabeth L. Altmaier, EM Kofoed, ER Neptune, Eric Boerwinkle, Eric E. Schadt, Erik Ingelsson, Erika Salvi, Eva Albrecht, F Galton, Fernando Rivadeneira, Florian Ernst, Francis S. Collins, Frank B. Hu, Fredrik Wiklund, G Lettre, G. Bragi Walters, G. Mark Lathrop, Gabrielle Boucher, Gert-Jan van Ommen, Gonneke Willemsen, Gonçalo R. Abecasis, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, Guillaume Lettre, Guillaume Paré, H.-Erich Wichmann, Hana Lango Allen, Harry Campbell, Heather M. Stringham, Heikki V. Huikuri, Helene Alavere, Henrik Grönberg, Henry Völzke, Heribert Schunkert, Hugh Watkins, Ida Surakka, Igor Rudan, Inga Prokopenko, Ingrid B. Borecki, Inke R. König, Inês Barroso, Irene Pichler, Iris M. Heid, Ivana Kolcic, J Yang, Jaakko Kaprio, Jaakko Tuomilehto, Jaana Laitinen, Jacques S. Beckmann, James F. Wilson, Jan H. Smit, Jeanette Erdmann, Jeffrey R. O’Connell, Jennie Hui, Jennifer G. Sambrook, Jerome I. Rotter, JH Park, Jian Yang, Jianfeng Xu, Jianjun Liu, Jianxin Shi, Jian’an Luan, Jing Hua Zhao, Joel N. Hirschhorn, Johan G. Eriksson, Johannes Kettunen, John D. Rioux, John F. Peden, John P. Beilby, John R. B. Perry, John R. Thompson, Jonathan P. Tyrer, Jorma Viikari, Joshua C. Randall, Joshua W. Knowles, Jouke-Jan Hottenga, Joyce B. J. van Meurs, Ju-Hyun Park, Jubao Duan, Juha Sinisalo, Julius Suh Ngwa, K Estrada, KA Frazer, Karen L. Mohlke, Kari E. North, Kari Stefansson, Karol Estrada, Katja K. Aben, Ke Hao, Ken Sin Lo, Keri L. Monda, Kevin B. Jacobs, Kirsi H. Pietiläinen, Kristin G. Ardlie, L. Adrienne Cupples, LA Hindorff, Lachlan Coin, Lambertus Kiemeney, Larry D. Atwood, Laura Zagato, Lee M. Kaplan, Leena Peltonen, Leif C. Groop, Lenore J. Launer, Liesbeth Vandenput, Liming Liang, Lina Zgaga, Lorena Citterio, Lu Qi, Lyle J. Palmer, M Weinstein, M. Carola Zillikens, M. Juhani Junttila, Manfred Kayser, Manuela Uda, Mari Nelis, Mari-Liis Tammesoo, Marja-Liisa Lokki, Marjo-Riitta Jarvelin, Marjolein J. Peters, Mark I. McCarthy, Mark J. Caulfield, Markku Koiranen, Markku S. Nieminen, Markus Perola, Martin den Heijer, Martin Farrall, Martin Ridderstråle, Martina Müller, Mary F. Feitosa, Massimo Mangino, Matthew N. Cooper, Mattias Lorentzon, Michael A. Province, Michael Boehnke, Michael C. Turchin, Michael E. Goddard, Michael N. Weedon, Michael Preuss, Michael Stumvoll, Mika Kähönen, MN Weedon, MN Weedon, N Soranzo, Najaf Amin, Nancy L. Heard-Costa, Neil R. Robertson, Nelson B. Freimer, Nicholas G. Martin, Nicholas J. Wareham, Nicola Glorioso, Nicole L. Glazer, Nicole Soranzo, Nigel W. Rayner, Niina Pellikka, Nilanjan Chatterjee, Nilesh J. Samani, Olle Melander, Olli Raitakari, Ozren Polasek, Paavo Zitting, Pablo V. Gejman, Panos Deloukas, Patricia B. Munroe, Paul Elliott, Paul M. Ridker, Per Hall, Peter Almgren, Peter Kovacs, Peter Kraft, Peter M. Visscher, Peter P. Pramstaller, PM Visscher, Quince Gibson, RA Fisher, Rany M. Salem, Reedik Mägi, Richard B. Hayes, Richard N. Bergman, Robert C. Kaplan, Robert J. Weyant, Robert W. Lawrence, Roberto Elosua, Ruth J. F. Loos, S Raychaudhuri, S Sanna, Sailaja Vedantam, Samuli Ripatti, Sarah H. Wild, Sekar Kathiresan, Seppo Koskinen, Serena Sanna, Shamika Ketkar, Shaun Purcell, Shen Haiqing, SM Purcell, Sonja I. Berndt, Soumya Raychaudhuri, SP Dickson, Stefan Schreiber, Stephen J. Chanock, Suzanne Rafelt, Sven Bergmann, TA Manolio, Talin Haritunians, Tamara B. Harris, Teresa Ferreira, Terho Lehtimäki, Themistocles L. Assimes, Thomas Illig, Thomas Kocher, Thomas Meitinger, Thomas Quertermous, Thomas W. Winkler, Thor Aspelund, Timothy D. Spector, Timothy M. Frayling, Toby Johnson, Tom H. Mosley Jr, Tomi Pastinen, Tony Kwan, Tsegaselassie Workalemahu, Tuomas O. Kilpeläinen, Tushar Bhangale, Tõnu Esko, Ulf Gyllensten, Ulla Sovio, Unnur Thorsteinsdottir, Valgerdur Steinthorsdottir, Veikko Salomaa, Veronique Vitart, Vilmundur Gudnason, Vincent Mooser, Wendy L. McArdle, Willem H. Ouwehand, Wilmar Igl, Wolfgang Hoffman, Yurii S. Aulchenko, Zoltán Kutalik, Åsa Johansson +319 morecore +6 more sourcesQuantitative trait loci for growth trajectories in Populus
Genetical Research, 2003 Growth trajectories are a biological process important to plant and animal breeding, and to evolutionary genetic studies. In this article, we report the detection of quantitative trait loci (QTLs) responsible for growth trajectories in poplars that are used as a model system for the study of forest biology.Rongling, Wu, Chang-Xing, Ma, Mark C K, Yang, Myron, Chang, Ramon C, Littell, Upasana, Santra, Samuel S, Wu, Tongming, Yin, Minren, Huang, Minxiu, Wang, George, Casella +10 moreopenaire +2 more sourcesCOMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom +6 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more source
