Results 131 to 140 of about 63,776 (234)

Neuron‐Derived Extracellular Vesicles: Emerging Biomarkers and Functional Mediators in Alzheimer's Disease, With Comparative Insights Into Neurodevelopment and Aging

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurodegenerative disorders characterized by the accumulation of amyloid‐β (Aβ) peptide and phosphorylated tau protein in the brain. Despite intensive efforts, early diagnosis and monitoring of AD remain challenging due to the lack of reliable biomarkers that can detect the disease in its ...
Ceren Perihan Gonul, Bilge Karacicek, Sermin Genc   +2 more
wiley   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, Volume 73, Issue 7, Page 1349-1364, July 2025.
Main Points Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain.
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

Deep Sequencing Reveals Dual Evolution of SARS‐CoV‐2: Insights Into Defective Genomes From Wuhan‐Hu‐1 Variants to Omicron Subvariants

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT SARS‐CoV‐2 has evolved from early variants dominating the first (B.1.5, B.1.1) and second (B.1.177) pandemic waves, which exhibited a higher frequency of minority mutants with deletions leading to Defective Viral Genomes (DVGs) in the spike region near the S1/S2 cleavage site than the Alpha, Beta, and Delta variants.
Carolina Campos, Marta Ibañez‐Lligoña, Sergi Colomer‑Castell, Josep Gregori, Damir Garcia‑Cehic, Cristina Andrés, Maria Piñana, Alejandra González‑Sánchez, Ariadna Rando‑Segura, Juliana Esperalba, Narcis Saubí, Maria Francesca Cortese, David Tabernero, Francisco Rodriguez‐Frias, Roser Ferrer, Juan Ignacio Esteban, Renate W. Kakze‐van der Honing, Andries A. Kampfraath, Júlia Vergara‐Alert, Joaquim Segalés, Wim H. M. van der Poel, Tomàs Pumarola, Andrés Antón, Josep Quer   +23 more
wiley   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

Comparative transcriptome analysis of PBMCs in cats diagnosed with and recovered from FIPV. [PDF]

Lab Anim Res
Lee JY, Cho HR, Oh HG, Hwang JH.
europepmc   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD). [PDF]

Elife
Deganutti G, Pipito L, Rujan RM, Weizmann T, Griffin P, Ciancetta A, Moro S, Reynolds CA.   +7 more
europepmc   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity. [PDF]

Toxins (Basel)
Iori S, Montanucci L, D'Onofrio C, Lahtela-Kakkonen M, Lucatello L, Bardhi A, Barbarossa A, Capolongo F, Zaghini A, Pauletto M, Dacasto M, Giantin M.   +11 more
europepmc   +1 more source