Results 141 to 150 of about 167,144 (276)

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg, M. Heber, L. Ries, K. Markus, N. Ksionsko, N. Schmidt, G. Nothnick, L. Thielking, M. O'Neill, S. Martínéz‐González, C. Blanco‐Aparicio, J. Pastor, D. Cunningham, R. Koch   +13 more
wiley   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

, 1986
Hiroshi Itoh, Tohru Kozasa, Shigekazu Nagata, Shun Nakamura, Toshiaki Katada, M Ui, Shigenori Iwai, Eiko Ohtsuka, Hiroshi Kawasaki, Kazuyuki Suzuki   +9 more
openalex   +1 more source

Extreme Neutral Outflow in an Inactive Quenching Galaxy at z$\sim$1.3 [PDF]

arXiv
We have discovered a substantial sodium doublet (Na D $\lambda\lambda$5890, 5896\AA)-traced neutral outflow in a quenching galaxy JADES-GS-206183 at $z=1.317$ in GOODS-S field. Its JWST NIRSpec/MSA spectrum shows a significantly blueshifted and deep Na D absorption, revealing a neutral outflow with a velocity of $v_{\rm out}=828^{+79}_{-49}\,\mathrm{km\
arxiv  

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]

, 2009
Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core   +1 more source

Neutron correlations and clustering in neutron-rich nuclear systems [PDF]

arXiv
In this paper, we will briefly review the recent progress on neutron correlations and clustering in neutron-rich nuclei from quasi-free scattering experiments. The quasi-free ($p$, $pn$) reaction was measured for Borromean nuclei $^{11}$Li, $^{14}$Be, and $^{17}$B. A surprisingly small $s$-wave component was found for $^{17}$B, revealing a weak neutron
arxiv  

Stbd1 stimulates AMPK signaling and alleviates insulin resistance in an in vitro hepatocyte model

The FEBS Journal, EarlyView.
Stbd1 is an N‐myristoylated, ER‐resident, glycogen‐binding protein whose loss‐of‐function has been associated with insulin resistance. We report that AML12 hepatocytes overexpressing either N‐myristoylated Stbd1 or a non‐N‐myristoylated variant display enhanced AMPK signaling and improved insulin sensitivity, independently of differences in glycogen ...
Andria Theodoulou, Thilo Speckmann, Louiza Potamiti, Otto Baba, Tsuyoshi Morita, Anthi Drousiotou, Mihalis I. Panayiotidis, Annette Schürmann, Petros P. Petrou   +8 more
wiley   +1 more source

Exploratory analyses of leukocyte responses in hospitalized patients treated with ozanimod following a severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection

Immunology &Cell Biology, EarlyView.
In this exploratory study on the putative mechanisms of action of ozanimod in the modulation of severe coronavirus disease 2019 (COVID‐19), we found that patients receiving standard of care plus ozanimod had reduced circulating monocytes and C–C motif ligand 2 (CCL2) levels, compared with patients receiving standard of care alone.
Olivier Courtemanche, Pascale Blais‐Lecours, Sylvie Lesage, Geneviève Chabot‐Roy, Lise Coderre, Marie‐Renée Blanchet, Nathalie Châteauvert, François Lellouche, David Marsolais   +8 more
wiley   +1 more source

European Guideline (EuroGuiDerm) on atopic eczema: Living update

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The updated guideline includes a new evidence‐based recommendation for the IL‐13 inhibitor lebrikizumab. In addition, the Janus kinase inhibitors baricitinib and abrocitinib, which were initially only approved for adult patients, are now also recommended for children from the age of 2 and adolescents from the age of 12, respectively.
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara‐Pinton, S. Christen‐Zaech, M. Deleuran, M. Dittmann, N. Fosse, K. Gáspár, L. A. A. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, S. Holland, C. G. Mortz, A. Nast, U. Nygaard, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra‐Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, R. N. Werner, C. Flohr   +31 more
wiley   +1 more source