Results 11 to 20 of about 71,714 (251)

Expression of constitutively active Gs alpha-subunits in GH3 pituitary cells stimulates prolactin promoter activity.

Journal of Biological Chemistry, 1994
Although G protein alpha subunits are known to regulate such cellular functions as growth and enzymatic activity, the ability of these proteins to regulate target gene expression has not yet been directly investigated. Transient expression in GH3 pituitary cells of a target rat prolactin promoter-chloramphenicol acetyltransferase construct, (-1957)PRL ...
J, Tian, J, Chen, C, Bancroft
openaire   +3 more sources

Genetic variants of the extra‐large stimulatory Gs protein alpha‐subunit and risk of thrombotic and haemorrhagic disorders [PDF]

British Journal of Haematology, 2004
SummaryA polymorphism of the gene encoding the extra‐large stimulatory G‐protein α‐subunit (XLαs), originally identified in three patients with a bleeding tendency, involved a 36‐bp insertion and two missense changes. A paternally‐inherited insertion displayed a moderate platelet Gsα over‐expression, which lead to platelet hypo‐reactivity.
R, González-Conejero, J, Corral, J A, Guerrero, J A, Iniesta, J, Rivera, F, de Arriba, V, Vicente   +6 more
openaire   +3 more sources

Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. [PDF]

Proceedings of the National Academy of Sciences, 1990
Affected members of most kindreds with Albright hereditary osteodystrophy have a partial deficiency of functional Gs, the guanine nucleotide-binding protein that stimulates adenylyl cyclase. By use of the polymerase chain reaction to amplify genomic fragments with the attachment of a high-melting G + C-rich region (GC clamp) and analysis of these ...
L S, Weinstein, P V, Gejman, E, Friedman, T, Kadowaki, R M, Collins, E S, Gershon, A M, Spiegel   +6 more
openaire   +3 more sources

Calcitonin values in pseudohypoparathyroidism [PDF]

Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2023
Pseudohypoparathyroidism type 1A is a rare endocrine disorder caused by GNAS mutation and the resulting hormone resistance at the receptor level, i.e. the activation of the intracellular pathway of the Gs alpha subunit is not possible.
Marković Bojan, Klet Sanja, Stojković Mirjana, Janić Tamara, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš   +6 more
doaj   +1 more source

Aptamer-based multiplexed proteomic technology for biomarker discovery [PDF]

, 2010
Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands
A Keller, AD Ellington, AI Nesvizhskii, Alana Sterkel, Alex Stewart, Alexey Wolfson, Allison Weiss, Andrew B. Dalby, AS Levey, AS Levey, Ashley Bock, Ashley Forbes, AW Bell, B Schweitzer, BE Eaton, Bharat Gawande, Brian Hicke, Bridget Lollo, Britta Singer, Bruce E. Eaton, C Borrebaeck, C Tuerk, Cate Fowler, Chi Zhang, Christopher Bock, D Schneider, D Venturoli, D Zichi, D Zichi, Dan Nieuwlandt, Daniel I. Resnicow, Daniel Levine, Daniel Schneider, Deborah Ayers, Dennis Halladay, Dom Zichi, Dylan Flather, Edward N. Brody, EN Brody, ES Gragoudas, Evaldas Katilius, Fabrizio Gelain, Glenn Sanders, Gregory Husar, HK Binz, IC van Riemsdijk-van Overbeeke, J Ninio, J Ruckman, J Silberring, JD Vaught, JD Vaught, Jeff Carter, Jeffrey J. Walker, Jennifer Bertino, Jim Heil, JJ Hopfield, Joe Heilig, John Rohloff, Jonathan D. Vaught, K Chaudhary, L Gold, L Liotta, LA Gugliotti, LA Stevens, Larry Gold, Luke Kroiss, M Famulok, M Pascual, Magda Gunn, Malti Nikrad, Martin Stanton, Matt Otis, Meredith Goss, Michele Nelson, Mike Mehan, Mike Vrkljan, Mike Watrobka, Nancy Kim, Nebojsa Janjic, Ngan Le, P Mitchell, R Aebersold, R Craig, R Vanholder, Rachel M. Ostroff, RD Jenison, RF Service, RM Ostroff, Robert Mehler, S Fredriksson, S Pan, SA Doggrell, Sally K. Nelson, Sarah Sattin, Shashi Gupta, Sheela Waugh, Sheri K. Wilcox, Stephan Kraemer, Steve Pietrasiewicz, Steven K. Wolk, Susan Jennings, Suzanne Stratford, SV Giannelli, T Dewey, TA Addona, Tad H. Koch, Thale Jarvis, Thomas Parker, Tim Fitzwater, TL Nickolas, TM Tarasow, Tracy R. Keeney, Trudi Foreman, Urs Ochsner, Wes Lindsey, Wes Mayfield   +115 more
core   +16 more sources

Competing activities of heterotrimeric G proteins in Drosophila wing maturation. [PDF]

PLoS ONE, 2010
Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the
Natalya Katanayeva, Damir Kopein, Reto Portmann, Daniel Hess, Vladimir L Katanaev   +4 more
doaj   +1 more source

Analysis of Physiological Variations and Genetic Architecture for Photosynthetic Capacity of Japanese Soybean Germplasm

Frontiers in Plant Science, 2022
The culmination of conventional yield improving parameters has widened the margin between food demand and crop yield, leaving the potential yield productivity to be bridged by the manipulation of photosynthetic processes in plants.
Mohammad Jan Shamim, Akito Kaga, Yu Tanaka, Hiroshi Yamatani, Tatsuhiko Shiraiwa   +4 more
doaj   +1 more source

Genome-Wide Association Study and Selective Sweep Analysis Reveal the Genetic Architecture of Body Weights in a Chicken F2 Resource Population

Frontiers in Veterinary Science, 2022
Rapid growth is one of the most important economic traits in broiler breeding programs. Identifying markers and genes for growth traits may not only benefit marker-assisted selection (MAS)/genomic selection (GS) but also provide important information for
Shouzhi Wang, Shouzhi Wang, Shouzhi Wang, Yuxiang Wang, Yuxiang Wang, Yuxiang Wang, Yudong Li, Yudong Li, Yudong Li, Fan Xiao, Huaishun Guo, Haihe Gao, Ning Wang, Ning Wang, Ning Wang, Hui Zhang, Hui Zhang, Hui Zhang, Hui Li, Hui Li, Hui Li   +20 more
doaj   +1 more source

Mangiferin: Analgesic properties in neuropathic pain, molecular docking and meta-analysis

Phytomedicine Plus, 2022
Aim: : To investigate the analgesic effects of mangiferin (MAF) in experimental neuropathic pain (NPP) models and underlying mechanism. Methods: : Databases including Pubmed, Web of Science, Embase, Cochrane Library, China national knowledge ...
Bo-tao Chang, Hui-zhong Jiang, Yi-jing Wei, Qiu-ju Gong, Dan Yu, Zhi-yu Dong, Jun Luo, Ying Gao, Qi Yao   +8 more
doaj   +1 more source

Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line. [PDF]

PLoS ONE, 2016
Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices. In the last several decades, some evidence has shown an association between ELF-MF exposure and depression and/or anxiety in epidemiological ...
Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku, Mitsuo Kitamura   +4 more
doaj   +1 more source