Results 11 to 20 of about 63,776 (234)
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. [PDF]
Proceedings of the National Academy of Sciences, 1990 Affected members of most kindreds with Albright hereditary osteodystrophy have a partial deficiency of functional Gs, the guanine nucleotide-binding protein that stimulates adenylyl cyclase. By use of the polymerase chain reaction to amplify genomic fragments with the attachment of a high-melting G + C-rich region (GC clamp) and analysis of these ...
Lee S. Weinstein +6 more
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Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. [PDF]
Proceedings of the National Academy of Sciences, 1988 Patients who have pseudohypoparathyroidism type I associated with Albright hereditary osteodystrophy commonly have a genetic deficiency of the alpha subunit of the G protein that stimulates adenylyl cyclase (alpha Gs) (ATP pyrophosphate-lyase, EC 4.6.1.1).
Michael A. Levine +7 more
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Genetic variants of the extra‐large stimulatory Gs protein alpha‐subunit and risk of thrombotic and haemorrhagic disorders [PDF]
British Journal of Haematology, 2004 SummaryA polymorphism of the gene encoding the extra‐large stimulatory G‐protein α‐subunit (XLαs), originally identified in three patients with a bleeding tendency, involved a 36‐bp insertion and two missense changes. A paternally‐inherited insertion displayed a moderate platelet Gsα over‐expression, which lead to platelet hypo‐reactivity.
Rocío Gónzález‐Conejero +6 more
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Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine. [PDF]
Gut, 1996 The stimulatory guanosine triphosphate (GTP) binding protein alpha subunit (Gs alpha) of adenylate cyclase is the target protein for cholera toxin.The expression of this signal transducer was analysed in the small intestine of developing rats by RNA transfer (northern blot) analysis by immunoblotting, and by ADP-ribosylation of membrane proteins ...
Ian R. Sanderson +5 more
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Journal of Biological Chemistry, 1994 Although G protein alpha subunits are known to regulate such cellular functions as growth and enzymatic activity, the ability of these proteins to regulate target gene expression has not yet been directly investigated. Transient expression in GH3 pituitary cells of a target rat prolactin promoter-chloramphenicol acetyltransferase construct, (-1957)PRL ...
Jiajun Tian, Jie Chen, C Bancroft
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Journal of Biological Chemistry, 1993 In endosomes the polymeric immunoglobulin receptor (pIgR) is sorted into transcytotic vesicles. Transcytosis of the pIgR in polarized Madin-Darby canine kidney (MDCK) cells is regulated both by phosphorylation of Ser664 and by binding of ligand, dimeric IgA (dIgA). Mutation of Ser664 to Ala (pIgR-Ala664) greatly reduces transcytosis of the pIgR without
Morgane Bomsel, Keith E. Mostov
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Journal of Biological Chemistry, 1993 Proteolytic removal and genetic deletion of the amino-terminal domain of G protein alpha subunit have shown that this region is necessary for interaction with beta gamma subunits. In the alpha subunits which undergo myristoylation, myristoylation of the amino-terminal glycine modulates the affinity of alpha subunit for the beta gamma complex.
Ronald van der Neut +4 more
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Journal of Biological Chemistry, 1991 Proteolytic experiments performed on transducin and Go alpha subunit strongly suggest that the amino-terminal residues of the alpha chain are involved in the interaction with beta gamma subunits. To test the possibility that the same region in Gs may fulfill a similar function, we introduced a deletion in the amino-terminal domain of Gs alpha.
Laurent Journot +3 more
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Calcitonin values in pseudohypoparathyroidism [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 2023 Pseudohypoparathyroidism type 1A is a rare endocrine disorder caused by GNAS mutation and the resulting hormone resistance at the receptor level, i.e. the activation of the intracellular pathway of the Gs alpha subunit is not possible.
Marković Bojan +6 more
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Competing activities of heterotrimeric G proteins in Drosophila wing maturation. [PDF]
PLoS ONE, 2010 Drosophila genome encodes six alpha-subunits of heterotrimeric G proteins. The Galphas alpha-subunit is involved in the post-eclosion wing maturation, which consists of the epithelial-mesenchymal transition and cell death, accompanied by unfolding of the
Natalya Katanayeva +4 more
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