Results 11 to 20 of about 167,144 (276)
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis. [PDF]
Proceedings of the National Academy of Sciences, 1990 Affected members of most kindreds with Albright hereditary osteodystrophy have a partial deficiency of functional Gs, the guanine nucleotide-binding protein that stimulates adenylyl cyclase. By use of the polymerase chain reaction to amplify genomic fragments with the attachment of a high-melting G + C-rich region (GC clamp) and analysis of these ...
Lee S. Weinstein +6 more
semanticscholar +6 more sources
Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine. [PDF]
Gut, 1996 The stimulatory guanosine triphosphate (GTP) binding protein alpha subunit (Gs alpha) of adenylate cyclase is the target protein for cholera toxin.The expression of this signal transducer was analysed in the small intestine of developing rats by RNA transfer (northern blot) analysis by immunoblotting, and by ADP-ribosylation of membrane proteins ...
Ian R. Sanderson +5 more
semanticscholar +6 more sources
Journal of Biological Chemistry, 1993 Proteolytic removal and genetic deletion of the amino-terminal domain of G protein alpha subunit have shown that this region is necessary for interaction with beta gamma subunits. In the alpha subunits which undergo myristoylation, myristoylation of the amino-terminal glycine modulates the affinity of alpha subunit for the beta gamma complex.
Ronald van der Neut +4 more
semanticscholar +5 more sources
Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. [PDF]
Proceedings of the National Academy of Sciences, 1988 Patients who have pseudohypoparathyroidism type I associated with Albright hereditary osteodystrophy commonly have a genetic deficiency of the alpha subunit of the G protein that stimulates adenylyl cyclase (alpha Gs) (ATP pyrophosphate-lyase, EC 4.6.1.1).
Michael A. Levine +7 more
semanticscholar +6 more sources
Diurnal regulation of metabolism by Gs-alpha in hypothalamic QPLOT neurons.
PLoS ONE, 2023 Neurons in the hypothalamic preoptic area (POA) regulate multiple homeostatic processes, including thermoregulation and sleep, by sensing afferent input and modulating sympathetic nervous system output.
Kevin D Gaitonde +7 more
doaj +2 more sources
Expression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells. [PDF]
Journal of Clinical Investigation, 1997 The manner in which growth factors acting at the cell surface regulate activity of myogenic basic-helix-loop-helix proteins in the nucleus and thus control the fate of committed skeletal myoblasts remains poorly understood. In this study, we report that immunoreactive Gs protein alpha-subunits (Gs alpha) localize to nuclei of proliferating C2C12 ...
Chang-Ru Tsai +2 more
openalex +4 more sources
Persistent activation of the α subunit of Gs promotes its removal from the plasma membrane [PDF]
Biochemical Journal, 1989 As assessed both by cholera-toxin-catalysed ADP-ribosylation and by immunoblotting with an anti-peptide antiserum raised against the C-terminal decapeptide of forms of Gs alpha (the alpha subunit of the stimulatory guanine nucleotide-binding protein), rat glioma C6 BU1 cells express two forms of Gs alpha: a major 44 kDa form and a much less prevalent ...
Cecilia G. Unson, Graeme Milligan
openaire +4 more sources
Journal of Biological Chemistry, 1993 The alpha subunit of the heterotrimeric Gs protein that couples the beta-adrenergic receptor to adenylyl cyclase undergoes post-translational palmitoylation. We examined the dynamics of this modification of alpha s by metabolic labeling of COS and S49 lymphoma cells under different conditions.
Michael Degtyarev +2 more
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Genetic variants of the extra‐large stimulatory Gs protein alpha‐subunit and risk of thrombotic and haemorrhagic disorders [PDF]
British Journal of Haematology, 2004 SummaryA polymorphism of the gene encoding the extra‐large stimulatory G‐protein α‐subunit (XLαs), originally identified in three patients with a bleeding tendency, involved a 36‐bp insertion and two missense changes. A paternally‐inherited insertion displayed a moderate platelet Gsα over‐expression, which lead to platelet hypo‐reactivity.
Rocío Gónzález‐Conejero +6 more
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Journal of Biological Chemistry, 1993 In endosomes the polymeric immunoglobulin receptor (pIgR) is sorted into transcytotic vesicles. Transcytosis of the pIgR in polarized Madin-Darby canine kidney (MDCK) cells is regulated both by phosphorylation of Ser664 and by binding of ligand, dimeric IgA (dIgA). Mutation of Ser664 to Ala (pIgR-Ala664) greatly reduces transcytosis of the pIgR without
Morgane Bomsel, Keith E. Mostov
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