Results 191 to 200 of about 63,776 (234)

Serotonergic Regulation in Alzheimer's Disease. [PDF]

Int J Mol Sci
Dolgacheva LP, Zinchenko VP, Nadeev AD, Goncharov NV.   +3 more
europepmc   +1 more source

PRKACB is a novel imprinted gene in marsupials. [PDF]

Epigenetics Chromatin
Newman T, Bond DM, Ishihara T, Rizzoli P, Gouil Q, Hore TA, Shaw G, Renfree MB.   +7 more
europepmc   +1 more source

Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease. [PDF]

Alzheimers Dement
Liu H, Bui Q, Hassenstab J, Gordon BA, Benzinger TLS, Timsina J, Sung YJ, Karch C, Renton AE, Daniels A, Morris JC, Xiong C, Ibanez L, Perrin RJ, Llibre-Guerra JJ, Day GS, Supnet-Bell C, Xu X, Berman SB, Chhatwal JP, Ikeuchi T, Kasuga K, Niimi Y, Huey ED, Schofield PR, Brooks WS, Ryan NS, Jucker M, Laske C, Levin J, Vöglein J, Roh JH, Lopera F, Bateman RJ, Cruchaga C, McDade EM, For DIAN study team.   +36 more
europepmc   +1 more source

Structure and dynamics determine G protein coupling specificity at a class A GPCR. [PDF]

Sci Adv
Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK.   +22 more
europepmc   +1 more source

Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions. [PDF]

Sci Adv
Brumm S, Gavrin A, Macleod M, Chesneau G, Usländer A, Schornack S.   +5 more
europepmc   +1 more source

Renal Hypokalemia: An Endocrine Perspective.

J Clin Endocrinol Metab
Culver SA, Suleman N, Kavuru V, Siragy HM.   +3 more
europepmc   +1 more source

Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.

The Journal of Clinical Endocrinology & Metabolism, 1992
Activating mutations of the Gs alpha subunit have been identified in a subset of somatotroph adenomas. The mutant form of the Gs alpha subunit causes persistent activation of adenylyl cyclase and consequently results in high intracellular levels of cAMP. Because cAMP is known to stimulate the synthesis of the glycoprotein hormone (GPH) alpha-subunit as
Philip E. Harris, J M Alexander, H A Bikkal, D W Hsu, E. T. Hedley‐Whyte, Anne Klibanski, J. Larry Jameson   +6 more
  +7 more sources

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

American Journal of Physiology-Heart and Circulatory Physiology, 1988
Specific guanine nucleotide-binding proteins (G proteins) couple receptors to calcium channels indirectly via cytoplasmic agents such as protein kinases (Birnbaumer et al., Kidney Int. 32: 514-537, 1987). Direct coupling between the stimulatory G protein from adenylyl cyclase (Gs) and calcium channels has been shown recently in inside-out cell-free ...
Yutaka Imoto, Atsuko Yatani, J P Reeves, Juan Codina, Lutz Birnbaumer, Arthur Brown   +5 more
openalex   +4 more sources

An unusual presentation of McCune-Albright syndrome confirmed by an activating mutation of the Gs alpha-subunit from a bone lesion

The Journal of Clinical Endocrinology & Metabolism, 1994
The McCune-Albright syndrome (MAS) is characterized clinically by polyostotic fibrous dysplasia, café-au-lait skin lesions, sexual precocity, and various other endocrinopathies. Recent investigations suggest an etiological role for embryonic somatic missense mutations that predict the substitution of a His or Cys for Arg at amino acid 201 of the Gs ...
Carl D. Malchoff
  +6 more sources

Effect of activating and inactivating mutations of GS-and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes

Journal of Cellular Biochemistry, 1997
Previous investigations have demonstrated that both Gs- and the Gi-family of GTP-binding proteins are implicated in differentiation of the 3T3-L1 preadipocyte. In order to further analyze the role of Gs alpha vs. Gi2 alpha, which are both involved in adenylate cyclase modulation, we transfected undifferentiated 3T3-L1 cells with two sets of G-protein ...
Jan O. Gordeladze, Kjerstin Elisabeth Høvik, John J. Merendino, Sylvie Hermouet, J. Silvio Gutkind, Domenico Accili   +5 more
openalex   +4 more sources