Results 191 to 200 of about 71,714 (251)

Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations

Journal of Clinical Endocrinology & Metabolism, 1992
Activating mutations of the Gs alpha subunit have been identified in a subset of somatotroph adenomas. The mutant form of the Gs alpha subunit causes persistent activation of adenylyl cyclase and consequently results in high intracellular levels of cAMP. Because cAMP is known to stimulate the synthesis of the glycoprotein hormone (GPH) alpha-subunit as
P E, Harris, J M, Alexander, H A, Bikkal, D W, Hsu, E T, Hedley-Whyte, A, Klibanski, J L, Jameson   +6 more
  +6 more sources

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

American Journal of Physiology-Heart and Circulatory Physiology, 1988
Specific guanine nucleotide-binding proteins (G proteins) couple receptors to calcium channels indirectly via cytoplasmic agents such as protein kinases (Birnbaumer et al., Kidney Int. 32: 514-537, 1987). Direct coupling between the stimulatory G protein from adenylyl cyclase (Gs) and calcium channels has been shown recently in inside-out cell-free ...
Y, Imoto, A, Yatani, J P, Reeves, J, Codina, L, Birnbaumer, A M, Brown   +5 more
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Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice

American Journal of Physiology-Cell Physiology, 1992
The adipocyte membrane G protein pattern, beta-adrenergic receptor activity, and adenylyl cyclase were determined in adipocyte membranes of the db/db mouse, a mutant that is a model of diabetes preceded by hyperinsulinemia, hyperglycemia, and extreme obesity. These studies were undertaken to determine whether the alterations already noted in the ob/ob
Nicole Bégin‐Heick
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Selectivity of the .beta.-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant .alpha. subunits in reconstituted phospholipid vesicles

Biochemistry, 1991
The selective regulation of Gs (long and short forms), Gi's (1, 2, and 3), and Go by the beta-adrenergic receptor was assessed quantitatively after coreconstitution of purified receptor, purified G-protein beta gamma subunits, and individual recombinant G-protein alpha subunits that were expressed in and purified from Escherichia coli.
R C, Rubenstein, M E, Linder, E M, Ross
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Mutation of glycine 49 to valine in the .alpha. subunit of Gs results in the constitutive elevation of cyclic AMP synthesis

Biochemistry, 1989
The G-protein GS couples hormone-activated receptors with adenylyl cyclase and stimulates increased cyclic AMP synthesis. Transient expression in COS-1 cells of cDNAs coding for the GS alpha-subunit (alpha S) or alpha S cDNAs having single amino acid mutations Gly49----Val or Gly225----Thr elevated cyclic AMP levels, resulting in the activation of ...
Woon, Chee-Wai, Heasley, Lynn, Osawa, Shoji, Johnson, Gary L.   +3 more
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Effect of activating and inactivating mutations of GS-and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes

Journal of Cellular Biochemistry, 1997
Previous investigations have demonstrated that both Gs- and the Gi-family of GTP-binding proteins are implicated in differentiation of the 3T3-L1 preadipocyte. In order to further analyze the role of Gs alpha vs. Gi2 alpha, which are both involved in adenylate cyclase modulation, we transfected undifferentiated 3T3-L1 cells with two sets of G-protein ...
J O, Gordeladze, K E, Høvik, J J, Merendino, S, Hermouet, S, Gutkind, D, Accili   +5 more
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A new constitutivelyactivating mutation of the Gs protein alpha subunit-gsp oncogene is found inhuman pituitary tumours

Oncogene, 1990
A new 227 Gln----Lys oncogenic mutation of the Gs alpha subunit (the GTP-binding protein that stimulates adenylyl cyclase) has been found in three out of eight human growth hormone-secreting pituitary tumours of the group 2, characterized by high cAMP and constitutively activated adenylyl cyclase.
Clementi E, Malgaretti N, Meldolesi J, TARAMELLI, ROBERTO   +3 more
  +5 more sources

Gs Alpha Subunit

, 2018
Sangdun Choi
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GTPase-inhibiting mutations in the alpha subunit of Gs.

Advances in second messenger and phosphoprotein research, 1990
S B, Masters, C A, Landis, H R, Bourne
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Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).

Endocrinology, 2009
GNAS gives rise to multiple imprinted gene products, including the alpha-subunit of the stimulatory G protein (Gs(alpha)) and its variant XL(alpha)s. Based on genomic sequence, the translation of XL(alpha)s begins from the middle of a long open reading frame, suggesting the existence of an N-terminally extended variant termed extralarge XLalphas (XXL ...
Cumhur, Aydin, Nurgul, Aytan, Mathew J, Mahon, Hesham A W, Tawfeek, Neil W, Kowall, Alpaslan, Dedeoglu, Murat, Bastepe   +6 more
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